Calcium dynamics and regulation in horizontal cells of the vertebrate retina: lessons from teleosts
- PMID: 27832601
- PMCID: PMC5288477
- DOI: 10.1152/jn.00585.2016
Calcium dynamics and regulation in horizontal cells of the vertebrate retina: lessons from teleosts
Abstract
Horizontal cells (HCs) are inhibitory interneurons of the vertebrate retina. Unlike typical neurons, HCs are chronically depolarized in the dark, leading to a constant influx of Ca2+ Therefore, mechanisms of Ca2+ homeostasis in HCs must differ from neurons elsewhere in the central nervous system, which undergo excitotoxicity when they are chronically depolarized or stressed with Ca2+ HCs are especially well characterized in teleost fish and have been used to unlock mysteries of the vertebrate retina for over one century. More recently, mammalian models of the retina have been increasingly informative for HC physiology. We draw from both teleost and mammalian models in this review, using a comparative approach to examine what is known about Ca2+ pathways in vertebrate HCs. We begin with a survey of Ca2+-permeable ion channels, exchangers, and pumps and summarize Ca2+ influx and efflux pathways, buffering, and intracellular stores. This includes evidence for Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors and N-methyl-d-aspartate receptors and for voltage-gated Ca2+ channels. Special attention is given to interactions between ion channels, to differences among species, and in which subtypes of HCs these channels have been found. We then discuss a number of unresolved issues pertaining to Ca2+ dynamics in HCs, including a potential role for Ca2+ in feedback to photoreceptors, the role for Ca2+-induced Ca2+ release, and the properties and functions of Ca2+-based action potentials. This review aims to highlight the unique Ca2+ dynamics in HCs, as these are inextricably tied to retinal function.
Keywords: calcium; horizontal cell; ion channels; retina; teleost.
Copyright © 2017 the American Physiological Society.
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References
-
- Akopian A, Krizaj D, Witkovsky P. Both high-and low voltage-activated calcium currents contribute to the light-evoked responses of luminosity horizontal cells in the Xenopus retina. Brain Res 762: 121–130, 1997. - PubMed
-
- Akopian A, McReynolds J, Weiler R. Short-term potentiation of off-responses in turtle horizontal cells. Brain Res 546: 132–138, 1991. - PubMed
-
- Akopian A, Witkovsky P. Modulation of transient outward potassium current by GTP, calcium, and glutamate in horizontal cells of the Xenopus retina. J Neurophysiol 71: 1661–1671, 1994. - PubMed
-
- Ariel M, Lasater EM, Mangel SC, Dowling JE. On the sensitivity of H1 horizontal cells of the carp retina to glutamate, aspartate and their agonists. Brain Res 295: 179–183, 1984. - PubMed
-
- Ariel M, Mangel SC, Dowling JE. N-methyl d-aspartate acts as an antagonist of the photoreceptor transmitter in the carp retina. Brain Res 372: 143–148, 1986. - PubMed
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