Review
doi: 10.1016/0009-3084(87)90050-8.
The role of iron in the initiation of lipid peroxidation
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- PMID: 2822270
- DOI: 10.1016/0009-3084(87)90050-8
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Review
The role of iron in the initiation of lipid peroxidation
Chem Phys Lipids.
1987 Jul-Sep.
Abstract
Iron is required for the initiation of lipid peroxidation. Evidence is presented that lipid peroxidation requires both Fe3+ and Fe2+, perhaps with oxygen to form a Fe3+-dioxygen-Fe2+ complex. Other mechanisms of initiation, mostly involving the iron-catalyzed formation of hydroxyl radical, are described and discussed from both theoretical and experimental view points.
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