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Review
. 2017 Sep:182:41-47.
doi: 10.1016/j.clim.2017.04.018. Epub 2017 May 3.

Genetics of Sjögren's syndrome

Leyla Y Teos  1 , Ilias Alevizos  2
Affiliations
Review

Genetics of Sjögren's syndrome

Leyla Y Teos et al. Clin Immunol. 2017 Sep.

Abstract

The pathogenesis of Sjögren's syndrome has not been elucidated. There has been evidence that genetics play an important role in the development of this disease from earlier studies. However, till now only a number of genes have been identified to be associated with SS, and these have only a weak or moderate effect. In this review we summarize the findings of the genetics studies and emphasize the need of large multicenter projects that will increase the sample sizes to provide more meaningful associations, as is the case in other common autoimmune diseases.

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Figures

Figure 1
Figure 1
A summary of the chromosomal localization of the genes identified in single candidate genes or GWAS studies. No discernible patterns are observed and no genes expressed in the X chromosome have been identified so far.
See this image and copyright information in PMC

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