doi: 10.1021/acs.orglett.7b01199.
Epub 2017 Jun 1.
Decarbonylative Cyanation of Amides by Palladium Catalysis
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- PMID: 28569059
- DOI: 10.1021/acs.orglett.7b01199
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Decarbonylative Cyanation of Amides by Palladium Catalysis
Org Lett.
.
Abstract
Transition-metal-catalyzed cyanation of aryl halides is a process of significant importance in the preparation pharmaceuticals, organic materials and agrochemicals. Here, we demonstrate a palladium-catalyzed decarbonylative cyanation of amides by highly selective carbon-nitrogen bond cleavage for the synthesis of a wide range of aryl nitriles. The utility of this technology is demonstrated by the synthesis of isotopically labeled aryl nitriles and orthogonal cross-coupling reactions of bench-stable amides to establish cross-coupling synthons with opposite polarity.
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