Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Mar:195:38-44.
doi: 10.1016/j.imlet.2017.08.022. Epub 2017 Aug 24.

Innate lymphoid cells and fibrotic regulation

Steven Horsburgh  1 , Stephen Todryk  1 , Andreas Ramming  2 , Jörg H W Distler  2 , Steven O'Reilly  3
Affiliations
Review

Innate lymphoid cells and fibrotic regulation

Steven Horsburgh et al. Immunol Lett. 2018 Mar.

Abstract

Innate lymphoid cells (ILCs) are innate immune cells that do not possess B or T cell receptors but belong to the lymphoid lineage. While these cells have not yet been extensively investigated since their classification as a homogenous group, emerging evidence suggests that they exert significant regulatory roles in both tissue remodelling and inflammation, and are therefore, also involved in fibrotic regulation. The following review will serve to outline the transcription factors, surface markers, and cytokines that define each subgroup, and the process by which these cells differentiate. Furthermore, the diverse functions of these cells in non-pathogenic states will be discussed, in addition to the interactions between ILCs and other cells of the immune system, both innate and adaptive, and how these pathways can elicit both pro- and anti-inflammatory and -fibrotic effects in varying tissues.

Keywords: Cytokines; Fibrosis; Inflammation; Lymphocytes; Scleroderma.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

LinkOut - more resources

-