Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Jan:150:137-149.
doi: 10.1016/j.biomaterials.2017.10.012. Epub 2017 Oct 4.

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

Tian Tian  1 , Hui-Xin Zhang  2 , Chun-Peng He  3 , Song Fan  4 , Yan-Liang Zhu  3 , Cui Qi  2 , Ning-Ping Huang  3 , Zhong-Dang Xiao  3 , Zu-Hong Lu  3 , Bakhos A Tannous  5 , Jun Gao  6
Affiliations

Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy

Tian Tian et al. Biomaterials. 2018 Jan.

Abstract

The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the treatment of cerebral ischemia given their unique properties, including low immunogenicity, innate stability, high delivery efficiency, and ability to cross the blood-brain barrier (BBB). However, exosome insufficient targeting capability limits their clinical applications. In this study, the c(RGDyK) peptide has been conjugated to the exosome surface by an easy, rapid, and bio-orthogonal chemistry. In the transient middle cerebral artery occlusion (MCAO) mice model, The engineered c(RGDyK)-conjugated exosomes (cRGD-Exo) target the lesion region of the ischemic brain after intravenous administration. Furthermore, curcumin has been loaded onto the cRGD-Exo, and administration of these exosomes has resulted in a strong suppression of the inflammatory response and cellular apoptosis in the lesion region. The results suggest a targeting delivery vehicle for ischemic brain based on exosomes and provide a strategy for the rapid and large-scale production of functionalized exosomes.

Keywords: Cerebral ischemia; Curcumin; Drug delivery; Exosomes.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles
-