Antiviral activity of five Asian medicinal pant crude extracts against highly pathogenic H5N1 avian influenza virus
- PMID: 29080615
- DOI: 10.1016/j.apjtm.2017.08.010
Antiviral activity of five Asian medicinal pant crude extracts against highly pathogenic H5N1 avian influenza virus
Abstract
Objective: To study the antiviral properties of the five Asian medicinal plants against in vitro infection by the highly pathogenic avian influenza virus (H5N1).
Methods: Crude extracts of Andrographis paniculata, Curcuma longa (C. longa), Gynostemma pentaphyllum, Kaempferia parviflora (K. parviflora), and Psidium guajava obtained by both water and ethanol extractions were investigated for their cytotoxicity in the Madin-Darby canine kidney cells. Thereafter, they were investigated in vitro for antiviral activity and cytokine response upon H5N1 virus infection.
Results: The results revealed that both water and ethanol extracts of all the five studied plants showed significant antiviral activity against H5N1 virus. Among these plants, C. longa and K. parviflora showed strong anti-H5N1 activity. Thus, they were selected for further studies on their cytokine response upon virus infection. It was found that ethanol and water crude extracts of C. longa and K. parviflora induced significant upregulation of TNF-α and IFN-β mRNA expressions, suggesting their roles in the inhibition of H5N1 virus replication.
Conclusions: To the best of the authors' knowledge, this study is among the earliest reports to illustrate the antiviral property of these Asian medicinal plants against the highly pathogenic avian H5N1 influenza virus. The results of this study shed light on alternative therapeutic sources for treatment of H5N1 influenza virus infection in the future.
Keywords: Antiviral activity; Cytokine response; H5N1 influenza virus; Medicinal plants.
Copyright © 2017 Hainan Medical University. Production and hosting by Elsevier B.V. All rights reserved.
Similar articles
-
14-Deoxy-11,12-dehydroandrographolide exerts anti-influenza A virus activity and inhibits replication of H5N1 virus by restraining nuclear export of viral ribonucleoprotein complexes.Antiviral Res. 2015 Jun;118:82-92. doi: 10.1016/j.antiviral.2015.03.008. Epub 2015 Mar 20. Antiviral Res. 2015. PMID: 25800824
-
Mycophenolic mofetil, an alternative antiviral and immunomodulator for the highly pathogenic avian influenza H5N1 virus infection.Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):298-304. doi: 10.1016/j.bbrc.2017.10.037. Epub 2017 Oct 7. Biochem Biophys Res Commun. 2017. PMID: 29017920
-
Differences in Type I interferon response in human lung epithelial cells infected by highly pathogenic H5N1 and low pathogenic H11N1 avian influenza viruses.Virus Genes. 2018 Jun;54(3):414-423. doi: 10.1007/s11262-018-1556-1. Epub 2018 Mar 24. Virus Genes. 2018. PMID: 29574656
-
High antiviral effects of hibiscus tea extract on the H5 subtypes of low and highly pathogenic avian influenza viruses.J Vet Med Sci. 2016 Oct 1;78(9):1405-1411. doi: 10.1292/jvms.16-0124. Epub 2016 May 19. J Vet Med Sci. 2016. PMID: 27193820 Free PMC article.
-
[Cytokine storm in avian influenza].Mikrobiyol Bul. 2008 Apr;42(2):365-80. Mikrobiyol Bul. 2008. PMID: 18697437 Review. Turkish.
Cited by
-
In vitro and in vivo action of turmeric oil (Curcuma longa L.) against Argulus spp. in goldfish (Carassius auratus).Open Vet J. 2023 Dec;13(12):1645-1653. doi: 10.5455/OVJ.2023.v13.i12.14. Epub 2023 Dec 31. Open Vet J. 2023. PMID: 38292719 Free PMC article.
-
A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis.Heliyon. 2023 Mar 10;9(3):e14386. doi: 10.1016/j.heliyon.2023.e14386. eCollection 2023 Mar. Heliyon. 2023. PMID: 36925514 Free PMC article. Review.
-
Ethnopharmacological Potential of Phytochemicals and Phytogenic Products against Human RNA Viral Diseases as Preventive Therapeutics.Biomed Res Int. 2023 Feb 20;2023:1977602. doi: 10.1155/2023/1977602. eCollection 2023. Biomed Res Int. 2023. PMID: 36860811 Free PMC article. Review.
-
Efficacy of Kan Jang® in Patients with Mild COVID-19: Interim Analysis of a Randomized, Quadruple-Blind, Placebo-Controlled Trial.Pharmaceuticals (Basel). 2022 Aug 17;15(8):1013. doi: 10.3390/ph15081013. Pharmaceuticals (Basel). 2022. PMID: 36015163 Free PMC article.
-
Enzymatic Biotransformation of Gypenoside XLIX into Gylongiposide I and Their Antiviral Roles against Enterovirus 71 In Vitro.Molecules. 2022 Jun 25;27(13):4094. doi: 10.3390/molecules27134094. Molecules. 2022. PMID: 35807341 Free PMC article.
LinkOut - more resources
Full Text Sources
Other Literature Sources