Respiratory Fungal Infections in Solid Organ and Hematopoietic Stem Cell Transplantation
- PMID: 29128021
- DOI: 10.1016/j.ccm.2017.07.013
Respiratory Fungal Infections in Solid Organ and Hematopoietic Stem Cell Transplantation
Abstract
Respiratory fungal infections are associated with high morbidity and mortality in hematopoietic stem cell (HSCT) and solid organ (SOT) transplant recipients, and are caused primarily by molds. Aspergillus is the most common pathogen. The net state of immunosuppression plays a major role in the risk of respiratory fungal infections after transplantation. Clinical presentation can be atypical and diagnosis can be delayed due to low sensitivity of diagnostic methods or inability to obtain adequate specimens. Fungal infections in HSCT and SOT carry a higher risk of dissemination. New prophylaxis strategies have changed the epidemiology of fungal infections in this patient population.
Keywords: Aspergillus; Fungal infection; Fungal pneumonia; Hematopoietic stem cell transplant; Solid organ transplant.
Copyright © 2017 Elsevier Inc. All rights reserved.
Similar articles
-
Respiratory Viral Infections in Solid Organ and Hematopoietic Stem Cell Transplantation.Clin Chest Med. 2017 Dec;38(4):707-726. doi: 10.1016/j.ccm.2017.07.012. Epub 2017 Sep 20. Clin Chest Med. 2017. PMID: 29128020 Free PMC article. Review.
-
Fungal colonization of the respiratory tract in allogeneic and autologous hematopoietic stem cell transplant recipients: a study of 573 transplanted patients.Med Sci Monit. 2015 Apr 24;21:1173-80. doi: 10.12659/MSM.893267. Med Sci Monit. 2015. PMID: 25907308 Free PMC article.
-
Fungal Pneumonia in Patients with Hematologic Malignancies and Hematopoietic Cell Transplantation.Clin Chest Med. 2017 Jun;38(2):279-294. doi: 10.1016/j.ccm.2016.12.006. Clin Chest Med. 2017. PMID: 28477639 Review.
-
Mycobacterial Infections in Solid Organ and Hematopoietic Stem Cell Transplantation.Clin Chest Med. 2017 Dec;38(4):761-770. doi: 10.1016/j.ccm.2017.07.011. Epub 2017 Sep 20. Clin Chest Med. 2017. PMID: 29128024 Review.
-
Viral Respiratory Tract Infections in Allogeneic Hematopoietic Stem Cell Transplantation Recipients in the Era of Molecular Testing.Biol Blood Marrow Transplant. 2018 Jul;24(7):1490-1496. doi: 10.1016/j.bbmt.2018.03.004. Epub 2018 Mar 9. Biol Blood Marrow Transplant. 2018. PMID: 29530766 Free PMC article. Review.
Cited by
-
Diagnosis and Treatment of Fungal Infections in Lung Transplant Recipients.Pathogens. 2023 May 10;12(5):694. doi: 10.3390/pathogens12050694. Pathogens. 2023. PMID: 37242364 Free PMC article. Review.
-
The diagnostic value of metagenomic next-generation sequencing for identifying Pneumocystis jirovecii infection in non-HIV immunocompromised patients.Front Cell Infect Microbiol. 2022 Oct 27;12:1026739. doi: 10.3389/fcimb.2022.1026739. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36389151 Free PMC article.
-
Clinical value of metagenomic next-generation sequencing by Illumina and Nanopore for the detection of pathogens in bronchoalveolar lavage fluid in suspected community-acquired pneumonia patients.Front Cell Infect Microbiol. 2022 Sep 27;12:1021320. doi: 10.3389/fcimb.2022.1021320. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36237436 Free PMC article.
-
Metagenomic Next-Generation Sequencing Successfully Detects Pulmonary Infectious Pathogens in Children With Hematologic Malignancy.Front Cell Infect Microbiol. 2022 Jun 28;12:899028. doi: 10.3389/fcimb.2022.899028. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35837477 Free PMC article.
-
Application of mNGS in the Etiological Analysis of Lower Respiratory Tract Infections and the Prediction of Drug Resistance.Microbiol Spectr. 2022 Feb 23;10(1):e0250221. doi: 10.1128/spectrum.02502-21. Epub 2022 Feb 16. Microbiol Spectr. 2022. PMID: 35171007 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
