The consequence of NAC on sodium arsenite-induced uterine oxidative stress
- PMID: 29511641
- PMCID: PMC5835492
- DOI: 10.1016/j.toxrep.2018.02.003
The consequence of NAC on sodium arsenite-induced uterine oxidative stress
Erratum in
-
Erratum regarding missing Declaration of Competing Interest statements in previously published articles.Toxicol Rep. 2020 Dec 25;8:62-63. doi: 10.1016/j.toxrep.2020.12.008. eCollection 2021. Toxicol Rep. 2020. PMID: 33391998 Free PMC article.
Abstract
Arsenic consumption through drinking water is a worldwide major health problem. Management of arsenic intoxication with invasive, painful therapy using metal chelators is usually used as a conventional treatment strategy in human. In this present study, we examined the efficacy of oral administration of N-acetyl l-cysteine (NAC) in limiting arsenic-mediated female reproductive disorders and oxidative stress in female Wistar rats. The treatment was continued for 8 days (2 estrus cycles) on rats with sodium arsenite (10 mg/Kg body weight) orally. We examined the electrozymographic imprint of three different enzymatic antioxidants in uterine tissue. Rats fed with sodium arsenite exhibited a significant lessening in the activities of superoxide dismutase (SOD), catalase and glutathione peroxidase (GPx). Uterine DNA breakage, necrosis, ovarian and uterine tissue damage, disruption in steroidogenesis were also found in arsenic treated rats. Co-administration of NAC at different doses (50 mg/kg body weight, 100 mg/kg body weight, respectively) significantly reversed the action of uterine oxidative stress markers like malondialdehyde (MDA), conjugated dienes (CD) and non protein soluble thiol (NPSH); and noticeably improved antioxidant status of the arsenic fed rats. This ultimately resulted in the uterine tissue repairing followed by improvement of ovarian steroidogenesis. However, this effective function of NAC might be crucial for the restoration of arsenic-induced female reproductive organ damage in rats.
Keywords: Arsenic; N-acetyl-l-cysteine; Oxidative stress; Uterus.
Figures
![None](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5835492/bin/fx1.gif)
![Fig. 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5835492/bin/gr1.gif)
![Fig. 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5835492/bin/gr2.gif)
![Fig. 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5835492/bin/gr3.gif)
![Fig. 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5835492/bin/gr4.gif)
Similar articles
-
Involvement of proinflammatory cytokines and metallothionein in the repairing of arsenic-mediated uterine tissue damage by curcumin.J Basic Clin Physiol Pharmacol. 2019 Jun 13;30(4). doi: 10.1515/jbcpp-2017-0179. J Basic Clin Physiol Pharmacol. 2019. PMID: 31199764
-
Association of Vitamin B12, Lactate Dehydrogenase, and Regulation of NF-κB in the Mitigation of Sodium Arsenite-Induced ROS Generation in Uterine Tissue by Commercially Available Probiotics.Probiotics Antimicrob Proteins. 2019 Mar;11(1):30-42. doi: 10.1007/s12602-017-9333-3. Probiotics Antimicrob Proteins. 2019. PMID: 28994024
-
Mitigation of arsenic driven utero-ovarian malfunction and changes of apoptotic gene expression by dietary NAC.Ecotoxicol Environ Saf. 2020 Aug;199:110675. doi: 10.1016/j.ecoenv.2020.110675. Epub 2020 May 8. Ecotoxicol Environ Saf. 2020. PMID: 32402895
-
Involvement of metallothionein, homocysteine and B-vitamins in the attenuation of arsenic-induced uterine disorders in response to the oral application of hydro-ethanolic extract of Moringa oleifera seed: a preliminary study.Drug Chem Toxicol. 2020 Jan;43(1):1-12. doi: 10.1080/01480545.2018.1508296. Epub 2018 Sep 13. Drug Chem Toxicol. 2020. PMID: 30208742
-
Effect of dietary co-administration of sodium selenite on sodium arsenite-induced ovarian and uterine disorders in mature albino rats.Toxicol Sci. 2003 Oct;75(2):412-22. doi: 10.1093/toxsci/kfg194. Epub 2003 Jul 25. Toxicol Sci. 2003. PMID: 12883085
Cited by
-
Update of the risk assessment of inorganic arsenic in food.EFSA J. 2024 Jan 18;22(1):e8488. doi: 10.2903/j.efsa.2024.8488. eCollection 2024 Jan. EFSA J. 2024. PMID: 38239496 Free PMC article.
-
Protective Effect of Dictyophora Polysaccharides on Sodium Arsenite-Induced Hepatotoxicity: A Proteomics Study.Front Pharmacol. 2021 Nov 26;12:749035. doi: 10.3389/fphar.2021.749035. eCollection 2021. Front Pharmacol. 2021. PMID: 34899304 Free PMC article.
-
Ethanol extract of Vitellaria paradoxa (Gaertn, F) leaves protects against sodium arsenite - induced toxicity in male wistar rats.Toxicol Rep. 2021 Apr 2;8:774-784. doi: 10.1016/j.toxrep.2021.03.035. eCollection 2021. Toxicol Rep. 2021. PMID: 33854955 Free PMC article.
-
Combination therapy of N-acetyl-L-cysteine and S-2(2-aminoethylamino) ethylphenyl sulfide for sulfur mustard induced oxidative stress in mice.Toxicol Rep. 2021 Mar 17;8:599-606. doi: 10.1016/j.toxrep.2021.03.011. eCollection 2021. Toxicol Rep. 2021. PMID: 33842212 Free PMC article.
-
The Hormetic Effect of Arsenic Trioxide on Rat Pulpal Cells: An In Vitro Preliminary Study.Eur J Dent. 2021 May;15(2):222-227. doi: 10.1055/s-0040-1718637. Epub 2020 Oct 30. Eur J Dent. 2021. PMID: 33126286 Free PMC article.
References
-
- Andersen O., Aaseth J. A review of pitfalls and progress in chelation treatment of metal poisonings. J. Trace. Elem. Med. Biol. 2016;38:74–80. - PubMed
-
- WHO . 2nd ed. Vol. 1. World Health Organization; Geneva: 1992. p. 41. (Guideline for Drinking Water Quality, Recommendation).
-
- Sengupta P., Banerjee R., Nath S., Das S., Banerjee S. Metals and female reproductive toxicity. Hum. Exp. Toxicol. 2015;34(7):679–697. - PubMed
LinkOut - more resources
Full Text Sources
Other Literature Sources