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Review

Indium In 111 White Blood Cells

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
Free Books & Documents
Review

Indium In 111 White Blood Cells

No authors listed.
Free Books & Documents

Excerpt

Information in this record refers to the use of indium In 111 white blood cells (In 111 leukocytes) as a diagnostic agent. Breastfeeding should be interrupted temporarily after administration of high doses of In 111 leukocytes to a nursing mother. British authorities state that doses greater than10MBq should not be administered to breastfeeding patients, and at that dose and below, no interruption of breastfeeding is required.[1] US recommendations state that a period of 6 days of interruption of breastfeeding is recommended, irrespective of dose.[2] The duration of breastfeeding interruption depends on the dose administered (see table). During the period of interruption, the breasts should be emptied regularly and completely. If the mother has expressed and saved milk prior to the examination, she can feed it to the infant during the period of nursing interruption.[1,3] The milk that is pumped by the mother during the time of breastfeeding interruption can either be discarded or stored frozen and given to the infant after 10 physical half-lives, or about 28 days, have elapsed. After doses greater than 10 MBq, consideration of temporarily limiting close contact between the mother and infant.[1]

Mothers concerned about the level of radioactivity in their milk could ask to have it tested at a nuclear medicine facility at their hospital. When the radioactivity is at a safe level, she may resume breastfeeding. A method for measuring milk radioactivity and determining the time when a mother can safely resume breastfeeding has been published.[4]

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References

    1. ARSAC notes for guidance: Good clinical practice in nuclear medicine. Notes for guidance on the clinical administration of radiopharmaceuticals and use of sealed radioactive sources. 2020. https://www.gov.uk/government/publications/arsac-notes-for-guidance - PubMed
    1. Dilsizian V, Metter D, Palestro C, Zanzonico P. Advisory Committee on Medical Uses of Isotopes (ACMUI) Sub-Committee on Nursing Mother Guidelines for the Medical Administration of Radioactive Material. Final report submitted: January 31, 2019. 2019. https://www.nrc.gov/docs/ML1903/ML19038A498.pdf
    1. Mountford PJ, Coakley AJ. A review of the secretion of radioactivity in human breast milk: Data, quantitative analysis and recommendations. Nucl Med Commun 1989;10:15-27. - PubMed
    1. Stabin MG, Breitz HB. Breast milk excretion of radiopharmaceuticals: Mechanisms, findings, and radiation dosimetry. J Nucl Med 2000;41:863-73. - PubMed

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