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Review

Diclofenac

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
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Review

Diclofenac

No authors listed.
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Excerpt

Data on excretion of diclofenac into milk are poor, but the drug has a short half-life and little glucuronide metabolite formation. Levels in milk appear to be quite low. Most reviewers consider diclofenac to be acceptable during breastfeeding.[1-5] Other agents having more published information may be preferred, especially while nursing a newborn or preterm infant.[6]

Maternal use of diclofenac topical gel or eye drops would not be expected to cause any adverse effects in breastfed infants. To substantially diminish the amount of drug that reaches the breastmilk after using eye drops, place pressure over the tear duct by the corner of the eye for 1 minute or more, then remove the excess solution with an absorbent tissue.

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References

    1. Brooks PM, Needs CJ. Antirheumatic drugs in pregnancy and lactation. Baillieres Clin Rheumatol 1990;4:157-71. - PubMed
    1. Østensen ME. Safety of non-steroidal anti-inflammatory drugs during pregnancy and lactation. Inflammopharmacology 1996;4:31-41. doi:10.1007/BF02735557 - DOI
    1. Spigset O, Hägg S. Analgesics and breast-feeding: Safety considerations. Paediatr Drugs 2000;2:223-38. - PubMed
    1. Janssen NM, Genta MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy and lactation. Arch Intern Med 2000;160:610-9. - PubMed
    1. MacGregor EA. Migraine in pregnancy and lactation. Neurol Sci 2014;35 (Suppl 1):61-4. - PubMed

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