Regulation of exoprotein gene expression in Staphylococcus aureus by agar
- PMID: 3007938
- DOI: 10.1007/BF00330517
Regulation of exoprotein gene expression in Staphylococcus aureus by agar
Abstract
Insertion of the erythromycin-resistance transposon Tn551 into the Staphylococcus aureus chromosome at a site which maps between the purB and ilv loci has a pleiotrophic effect on the production of a number of extracellular proteins. Production of alpha, beta and delta hemolysin, toxic shock syndrome toxin (TSST-1) and staphylokinase was depressed about fifty-fold while protein A production was elevated twenty-fold. Hybridization analysis showed that the defect in expression of TSST-1 and alpha hemolysin was at the transcriptional level. Inability of the mutant strain to express either a cloned TSST-1 gene or the chromosomal gene indicates that the transposon has inactivated a trans-active positive control element. This element has been designated agr for accessory gene regulator.
Similar articles
-
Cloning, characterization, and sequencing of an accessory gene regulator (agr) in Staphylococcus aureus.J Bacteriol. 1988 Sep;170(9):4365-72. doi: 10.1128/jb.170.9.4365-4372.1988. J Bacteriol. 1988. PMID: 2457579 Free PMC article.
-
Regulation of exoprotein expression in Staphylococcus aureus by a locus (sar) distinct from agr.Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6462-6. doi: 10.1073/pnas.89.14.6462. Proc Natl Acad Sci U S A. 1992. PMID: 1321441 Free PMC article.
-
The role of the delta-lysin gene (hld) in the regulation of virulence genes by the accessory gene regulator (agr) in Staphylococcus aureus.EMBO J. 1990 May;9(5):1391-9. doi: 10.1002/j.1460-2075.1990.tb08254.x. EMBO J. 1990. PMID: 2328718 Free PMC article.
-
Regulation of toxic shock syndrome toxin-1 gene in Staphylococcus aureus.Mol Cells. 1997 Feb 28;7(1):28-33. Mol Cells. 1997. PMID: 9085261
-
The extracellular protein regulator (xpr) affects exoprotein and agr mRNA levels in Staphylococcus aureus.J Bacteriol. 1993 Dec;175(24):7875-9. doi: 10.1128/jb.175.24.7875-7879.1993. J Bacteriol. 1993. PMID: 7504665 Free PMC article.
Cited by
-
A short-lived peptide signal regulates cell-to-cell communication in Listeria monocytogenes.Commun Biol. 2024 Aug 3;7(1):942. doi: 10.1038/s42003-024-06623-6. Commun Biol. 2024. PMID: 39097633 Free PMC article.
-
Molecular Mechanisms of Bacterial Resistance to Antimicrobial Peptides in the Modern Era: An Updated Review.Microorganisms. 2024 Jun 21;12(7):1259. doi: 10.3390/microorganisms12071259. Microorganisms. 2024. PMID: 39065030 Free PMC article. Review.
-
Mutations in the Staphylococcus aureus Global Regulator CodY Confer Tolerance to an Interspecies Redox-Active Antimicrobial.bioRxiv [Preprint]. 2024 Jul 3:2024.07.02.601769. doi: 10.1101/2024.07.02.601769. bioRxiv. 2024. PMID: 39040146 Free PMC article. Preprint.
-
FapR regulates HssRS-mediated heme homeostasis in Bacillus anthracis.bioRxiv [Preprint]. 2024 Jul 8:2024.07.08.602573. doi: 10.1101/2024.07.08.602573. bioRxiv. 2024. PMID: 39026866 Free PMC article. Preprint.
-
Chemical and biomolecular insights into the Staphylococcus aureus agr quorum sensing system: Current progress and ongoing challenges.Isr J Chem. 2023 Jun;63(5-6):e202200096. doi: 10.1002/ijch.202200096. Epub 2023 Mar 16. Isr J Chem. 2023. PMID: 38765792 Free PMC article.
References
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources