doi: 10.1016/0092-8674(86)90363-6.
Demonstration of virus-specific transcriptional activator(s) in cells infected with HTLV-III by an in vitro cell-free system
- PMID: 3019564
- DOI: 10.1016/0092-8674(86)90363-6
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Demonstration of virus-specific transcriptional activator(s) in cells infected with HTLV-III by an in vitro cell-free system
Cell.
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Abstract
Human T cell lymphotropic viruses (HTLV's) differ from most other retroviruses based on the presence of trans-regulatory genes for virus expression. In this study, using an in vitro cell-free transcription system, we demonstrate that nuclear extracts obtained from cells infected with HTLV-III (human immunodeficiency virus, HIV) contain a factor(s) that stimulates transcription specifically from the HTLV-III promoter. Present studies indicate that this activation is mainly involved in the initiation of transcription from the HTLV-III promoter.
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