More Than the Sum of Its Parts: Single-Cell Transcriptomics Reveals Epidermal Cell States

doi:10.1016/j.celrep.2018.10.041

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. 2018 Oct 23;25(4):823-824.

doi: 10.1016/j.celrep.2018.10.041.

More Than the Sum of Its Parts: Single-Cell Transcriptomics Reveals Epidermal Cell States

Ka-Wai Mok¹, Nivedita Saxena², Michael Rendl³

Affiliations

¹ Black Family Stem Cell Institute, Department of Cell, Developmental and Regenerative Biology, Department of Dermatology, Icahn School of Medicine at Mount Sinai, NY 10029, USA.
² Black Family Stem Cell Institute, Department of Cell, Developmental and Regenerative Biology, Department of Dermatology, Icahn School of Medicine at Mount Sinai, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, NY 10029, USA.
³ Black Family Stem Cell Institute, Department of Cell, Developmental and Regenerative Biology, Department of Dermatology, Icahn School of Medicine at Mount Sinai, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, NY 10029, USA. Electronic address: michael.rendl@mssm.edu.

PMID: 30355488
DOI: 10.1016/j.celrep.2018.10.041

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More Than the Sum of Its Parts: Single-Cell Transcriptomics Reveals Epidermal Cell States

Ka-Wai Mok et al. Cell Rep. 2018.

Free article

. 2018 Oct 23;25(4):823-824.

doi: 10.1016/j.celrep.2018.10.041.

Authors

Ka-Wai Mok¹, Nivedita Saxena², Michael Rendl³

Affiliations

¹ Black Family Stem Cell Institute, Department of Cell, Developmental and Regenerative Biology, Department of Dermatology, Icahn School of Medicine at Mount Sinai, NY 10029, USA.
² Black Family Stem Cell Institute, Department of Cell, Developmental and Regenerative Biology, Department of Dermatology, Icahn School of Medicine at Mount Sinai, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, NY 10029, USA.
³ Black Family Stem Cell Institute, Department of Cell, Developmental and Regenerative Biology, Department of Dermatology, Icahn School of Medicine at Mount Sinai, NY 10029, USA; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, NY 10029, USA. Electronic address: michael.rendl@mssm.edu.

PMID: 30355488
DOI: 10.1016/j.celrep.2018.10.041

Abstract

Compared to mouse models, less is known about human epidermal cell states and differentiation. In this issue of Cell Reports, Cheng et al. (2018) dissect the cell states and heterogeneity in human epidermis with large-scale transcriptomics of 92,889 single epidermal cells from normal and inflamed skin.

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Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution.
Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. Cheng JB, et al. Cell Rep. 2018 Oct 23;25(4):871-883. doi: 10.1016/j.celrep.2018.09.006. Cell Rep. 2018. PMID: 30355494 Free PMC article.

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Transcriptome Profiling Analyses in Psoriasis: A Dynamic Contribution of Keratinocytes to the Pathogenesis.
Rioux G, Ridha Z, Simard M, Turgeon F, Guérin SL, Pouliot R. Rioux G, et al. Genes (Basel). 2020 Sep 30;11(10):1155. doi: 10.3390/genes11101155. Genes (Basel). 2020. PMID: 33007857 Free PMC article. Review.

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More Than the Sum of Its Parts: Single-Cell Transcriptomics Reveals Epidermal Cell States

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More Than the Sum of Its Parts: Single-Cell Transcriptomics Reveals Epidermal Cell States

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