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. 1987 May;55(5):513-6.
doi: 10.1038/bjc.1987.104.

Epidermal growth factor receptors in non-small cell lung cancer

D Veale, T Ashcroft, C Marsh, G J Gibson, A L Harris
Free PMC article

Epidermal growth factor receptors in non-small cell lung cancer

D Veale et al. Br J Cancer. 1987 May.
Free PMC article

Abstract

The epidermal growth factor receptor is homologous to the oncogene erb-beta and is the receptor for a class of tumour growth factors (TGF-alpha). The clinical correlations with its expression were studied in 77 non-small cell lung cancers (NSCLC). They were stained for epidermal growth factor receptor (EGFr) by means of an indirect immunoperoxidase technique using a monoclonal antibody against the receptor. Normal lung tissue and normal bronchus were stained for comparison. Cancer tissue showed significantly increased staining compared to normal lung (P less than 0.05). Staining for EGFr in 40 squamous carcinomas was significantly stronger than in 37 specimens of other types of NSCLC (P less than 0.05), and staining in stage three NSCLC was stronger than in stage 1 and 2 (P less than 0.05). These results suggest that the presence of a high intensity of staining for EGF receptor is associated with spread of human non-small cell lung cancer and this receptor may be a suitable target for therapy.

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References

    1. Am J Roentgenol Radium Ther Nucl Med. 1974 Jan;120(1):130-8 - PubMed
    1. Br J Cancer. 1986 Aug;54(2):265-9 - PubMed
    1. Am J Clin Pathol. 1979 May;71(5):483-8 - PubMed
    1. Annu Rev Biochem. 1979;48:193-216 - PubMed
    1. N Engl J Med. 1980 Oct 9;303(15):878-80 - PubMed
-