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Review
. 2018 Oct 18:9:1487.
doi: 10.3389/fphys.2018.01487. eCollection 2018.

Mitochondria, Oxidative Stress and Innate Immunity

Yuxin Chen  1 , Zhongyang Zhou  2 , Wang Min  2   3
Affiliations
Review

Mitochondria, Oxidative Stress and Innate Immunity

Yuxin Chen et al. Front Physiol. .

Abstract

Canonical functions of mitochondria include the regulation of cellular survival, orchestration of anabolic and metabolic pathways, as well as reactive oxygen species (ROS) signaling. Recent discoveries, nevertheless, have demonstrated that mitochondria are also critical elements to stimulate innate immune signaling cascade that is able to intensify the inflammation upon cytotoxic stimuli beyond microbial infection. Here we review the expanding research field of mitochondria and oxidative stress in innate immune system to highlight the new mechanistic insights and discuss the pathological relevance of mitochondrial dysregulation induced aberrant innate immune responses in a growing list of sterile inflammatory diseases.

Keywords: ROS; inflammasome; innate and adaptive immune response; mitochondria; thioredoxin.

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Figures

FIGURE 1
FIGURE 1
Mechanism of mitochondria-mediated signaling in innate immunity. Mitochondria-derived ROS and released mtDNA directly induces activation of innate immune responses, including activation of inflammasome, sGAS-STING, and NF-kB signaling pathways. See text for details.
See this image and copyright information in PMC

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