Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Dec 5;10(470):eaau5516.
doi: 10.1126/scitranslmed.aau5516.

Noncoding regions are the main source of targetable tumor-specific antigens

Céline M Laumont  1   2 , Krystel Vincent  1   2 , Leslie Hesnard  1   2 , Éric Audemard  1 , Éric Bonneil  1 , Jean-Philippe Laverdure  1 , Patrick Gendron  1 , Mathieu Courcelles  1 , Marie-Pierre Hardy  1 , Caroline Côté  1 , Chantal Durette  1 , Charles St-Pierre  1   2 , Mohamed Benhammadi  1   2 , Joël Lanoix  1 , Suzanne Vobecky  3 , Elie Haddad  3 , Sébastien Lemieux  1   4 , Pierre Thibault  1   5 , Claude Perreault  6   2
Affiliations

Noncoding regions are the main source of targetable tumor-specific antigens

Céline M Laumont et al. Sci Transl Med. .

Abstract

Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but few have been identified thus far. We therefore developed a proteogenomic approach to enable the high-throughput discovery of TSAs coded by potentially all genomic regions. In two murine cancer cell lines and seven human primary tumors, we identified a total of 40 TSAs, about 90% of which derived from allegedly noncoding regions and would have been missed by standard exome-based approaches. Moreover, most of these TSAs derived from nonmutated yet aberrantly expressed transcripts (such as endogenous retroelements) that could be shared by multiple tumor types. Last, we demonstrated that, in mice, the strength of antitumor responses after TSA vaccination was influenced by two parameters that can be estimated in humans and could serve for TSA prioritization in clinical studies: TSA expression and the frequency of TSA-responsive T cells in the preimmune repertoire. In conclusion, the strategy reported herein could considerably facilitate the identification and prioritization of actionable human TSAs.

PubMed Disclaimer

Comment in

  • Expanding the search.
    Dart A. Dart A. Nat Rev Cancer. 2019 Mar;19(3):126-127. doi: 10.1038/s41568-018-0101-9. Nat Rev Cancer. 2019. PMID: 30617268 No abstract available.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources

-