Exploring phylogeny to find the function of sleep

doi:10.1038/s41583-018-0098-9

Review

. 2019 Feb;20(2):109-116.

doi: 10.1038/s41583-018-0098-9.

Exploring phylogeny to find the function of sleep

Ron C Anafi^{1

2}, Matthew S Kayser^{2

3}, David M Raizen^{4

5

6}

Affiliations

¹ Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
² Center for Sleep and Circadian Neurobiology and the Program for Chronobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
³ Department of Psychiatry and Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
⁴ Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. raizen@pennmedicine.upenn.edu.
⁵ Center for Sleep and Circadian Neurobiology and the Program for Chronobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. raizen@pennmedicine.upenn.edu.
⁶ Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. raizen@pennmedicine.upenn.edu.

PMID: 30573905
DOI: 10.1038/s41583-018-0098-9

Review

Exploring phylogeny to find the function of sleep

Ron C Anafi et al. Nat Rev Neurosci. 2019 Feb.

. 2019 Feb;20(2):109-116.

doi: 10.1038/s41583-018-0098-9.

Authors

Ron C Anafi^{1

2}, Matthew S Kayser^{2

3}, David M Raizen^{4

5

6}

Affiliations

¹ Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
² Center for Sleep and Circadian Neurobiology and the Program for Chronobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
³ Department of Psychiatry and Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
⁴ Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. raizen@pennmedicine.upenn.edu.
⁵ Center for Sleep and Circadian Neurobiology and the Program for Chronobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. raizen@pennmedicine.upenn.edu.
⁶ Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. raizen@pennmedicine.upenn.edu.

PMID: 30573905
DOI: 10.1038/s41583-018-0098-9

Abstract

During sleep, animals do not eat, reproduce or forage. Sleeping animals are vulnerable to predation. Yet, the persistence of sleep despite evolutionary pressures, and the deleterious effects of sleep deprivation, indicate that sleep serves a function or functions that cannot easily be bypassed. Recent research demonstrates sleep to be phylogenetically far more pervasive than previously appreciated; it is possible that the very first animals slept. Here, we give an overview of sleep across various species, with the aim of determining its original purpose. Sleep exists in animals without cephalized nervous systems and can be influenced by non-neuronal signals, including those associated with metabolic rhythms. Together, these observations support the notion that sleep serves metabolic functions in neural and non-neural tissues.

PubMed Disclaimer

Cited by

Orexin Neurons to Sublaterodorsal Tegmental Nucleus Pathway Prevents Sleep Onset REM Sleep-Like Behavior by Relieving the REM Sleep Pressure.
Feng H, Qiao QC, Luo QF, Zhou JY, Lei F, Chen Y, Wen SY, Chen WH, Pang YJ, Hu ZA, Jiang YB, Zhang XY, Zhou TY, Zhang XY, Yang N, Zhang J, Hu R. Feng H, et al. Research (Wash D C). 2024 Apr 30;7:0355. doi: 10.34133/research.0355. eCollection 2024. Research (Wash D C). 2024. PMID: 38694202 Free PMC article.
Sleep pressure modulates single-neuron synapse number in zebrafish.
Suppermpool A, Lyons DG, Broom E, Rihel J. Suppermpool A, et al. Nature. 2024 May;629(8012):639-645. doi: 10.1038/s41586-024-07367-3. Epub 2024 May 1. Nature. 2024. PMID: 38693264 Free PMC article.
A midbrain GABAergic circuit constrains wakefulness in a mouse model of stress.
Ren S, Zhang C, Yue F, Tang J, Zhang W, Zheng Y, Fang Y, Wang N, Song Z, Zhang Z, Zhang X, Qin H, Wang Y, Xia J, Jiang C, He C, Luo F, Hu Z. Ren S, et al. Nat Commun. 2024 Mar 28;15(1):2722. doi: 10.1038/s41467-024-46707-9. Nat Commun. 2024. PMID: 38548744 Free PMC article.
New alleles of nlp-2 , nlp-22 , and nlp-23 demonstrate that they are dispensable for stress-induced sleep in C. elegans.
Aviles S, Subramanian S, Nelson MD. Aviles S, et al. MicroPubl Biol. 2024 Feb 1;2024:10.17912/micropub.biology.001109. doi: 10.17912/micropub.biology.001109. eCollection 2024. MicroPubl Biol. 2024. PMID: 38371321 Free PMC article.
Age Differences in the Association of Sleep Duration Trajectory With Cancer Risk and Cancer-Specific Mortality: Prospective Cohort Study.
Liu C, Zhang Q, Liu C, Liu T, Song M, Zhang Q, Xie H, Lin S, Ren J, Chen Y, Zheng X, Shi J, Deng L, Shi H, Wu S. Liu C, et al. JMIR Public Health Surveill. 2024 Feb 7;10:e50836. doi: 10.2196/50836. JMIR Public Health Surveill. 2024. PMID: 38324354 Free PMC article.

See all "Cited by" articles

References

1. Zhdanova, I. V., Wang, S. Y., Leclair, O. U. & Danilova, N. P. Melatonin promotes sleep-like state in zebrafish. Brain Res. 903, 263–268 (2001). - PubMed
1. Tobler, I. Effect of forced locomotion on the rest–activity cycle of the cockroach. Behav. Brain Res. 8, 351–360 (1983). - PubMed
1. Raizen, D. M. et al. Lethargus is a Caenorhabditis elegans sleep-like state. Nature 451, 569–572 (2008). - PubMed
1. Vorster, A. P., Krishnan, H. C., Cirelli, C. & Lyons, L. C. Characterization of sleep in Aplysia californica. Sleep 37, 1453–1463 (2014). - PubMed - PMC
1. Omond, S. et al. Inactivity is nycthemeral, endogenously generated, homeostatically regulated, and melatonin modulated in a free-living platyhelminth flatworm. Sleep 40, zsx124 (2017).

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

K08 NS090461/NS/NINDS NIH HHS/United States

LinkOut - more resources

Full Text Sources
- Nature Publishing Group

[1] Zhdanova, I. V., Wang, S. Y., Leclair, O. U. & Danilova, N. P. Melatonin promotes sleep-like state in zebrafish. Brain Res. 903, 263–268 (2001). - PubMed

[2] Zhdanova, I. V., Wang, S. Y., Leclair, O. U. & Danilova, N. P. Melatonin promotes sleep-like state in zebrafish. Brain Res. 903, 263–268 (2001). - PubMed

[3] Tobler, I. Effect of forced locomotion on the rest–activity cycle of the cockroach. Behav. Brain Res. 8, 351–360 (1983). - PubMed

[4] Tobler, I. Effect of forced locomotion on the rest–activity cycle of the cockroach. Behav. Brain Res. 8, 351–360 (1983). - PubMed

[5] Raizen, D. M. et al. Lethargus is a Caenorhabditis elegans sleep-like state. Nature 451, 569–572 (2008). - PubMed

[6] Raizen, D. M. et al. Lethargus is a Caenorhabditis elegans sleep-like state. Nature 451, 569–572 (2008). - PubMed

[7] Vorster, A. P., Krishnan, H. C., Cirelli, C. & Lyons, L. C. Characterization of sleep in Aplysia californica. Sleep 37, 1453–1463 (2014). - PubMed - PMC

[8] Vorster, A. P., Krishnan, H. C., Cirelli, C. & Lyons, L. C. Characterization of sleep in Aplysia californica. Sleep 37, 1453–1463 (2014). - PubMed - PMC

[9] Omond, S. et al. Inactivity is nycthemeral, endogenously generated, homeostatically regulated, and melatonin modulated in a free-living platyhelminth flatworm. Sleep 40, zsx124 (2017).

[10] Omond, S. et al. Inactivity is nycthemeral, endogenously generated, homeostatically regulated, and melatonin modulated in a free-living platyhelminth flatworm. Sleep 40, zsx124 (2017).

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Exploring phylogeny to find the function of sleep

Affiliations

Exploring phylogeny to find the function of sleep

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources