iPseU-CNN: Identifying RNA Pseudouridine Sites Using Convolutional Neural Networks
- PMID: 31048185
- PMCID: PMC6488737
- DOI: 10.1016/j.omtn.2019.03.010
iPseU-CNN: Identifying RNA Pseudouridine Sites Using Convolutional Neural Networks
Abstract
Pseudouridine is the most prevalent RNA modification and has been found in both eukaryotes and prokaryotes. Currently, pseudouridine has been demonstrated in several kinds of RNAs, such as small nuclear RNA, rRNA, tRNA, mRNA, and small nucleolar RNA. Therefore, its significance to academic research and drug development is understandable. Through biochemical experiments, the pseudouridine site identification has produced good outcomes, but these lab exploratory methods and biochemical processes are expensive and time consuming. Therefore, it is important to introduce efficient methods for identification of pseudouridine sites. In this study, an intelligent method for pseudouridine sites using the deep-learning approach was developed. The proposed prediction model is called iPseU-CNN (identifying pseudouridine by convolutional neural networks). The existing methods used handcrafted features and machine-learning approaches to identify pseudouridine sites. However, the proposed predictor extracts the features of the pseudouridine sites automatically using a convolution neural network model. The iPseU-CNN model yields better outcomes than the current state-of-the-art models in all evaluation parameters. It is thus highly projected that the iPseU-CNN predictor will become a helpful tool for academic research on pseudouridine site prediction of RNA, as well as in drug discovery.
Keywords: RNA; convolution neural network; deep learning; iPseU-CNN; pseudouridine sites.
Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.
Figures
Similar articles
-
iPseU-NCP: Identifying RNA pseudouridine sites using random forest and NCP-encoded features.BMC Genomics. 2019 Dec 30;20(Suppl 10):971. doi: 10.1186/s12864-019-6357-y. BMC Genomics. 2019. PMID: 31888464 Free PMC article.
-
iPseU-Layer: Identifying RNA Pseudouridine Sites Using Layered Ensemble Model.Interdiscip Sci. 2020 Jun;12(2):193-203. doi: 10.1007/s12539-020-00362-y. Epub 2020 Mar 13. Interdiscip Sci. 2020. PMID: 32170573
-
Identification of RNA pseudouridine sites using deep learning approaches.PLoS One. 2021 Feb 23;16(2):e0247511. doi: 10.1371/journal.pone.0247511. eCollection 2021. PLoS One. 2021. PMID: 33621235 Free PMC article.
-
PseUdeep: RNA Pseudouridine Site Identification with Deep Learning Algorithm.Front Genet. 2021 Nov 18;12:773882. doi: 10.3389/fgene.2021.773882. eCollection 2021. Front Genet. 2021. PMID: 34868261 Free PMC article. Review.
-
Convolutional neural networks: an overview and application in radiology.Insights Imaging. 2018 Aug;9(4):611-629. doi: 10.1007/s13244-018-0639-9. Epub 2018 Jun 22. Insights Imaging. 2018. PMID: 29934920 Free PMC article. Review.
Cited by
-
PseUpred-ELPSO Is an Ensemble Learning Predictor with Particle Swarm Optimizer for Improving the Prediction of RNA Pseudouridine Sites.Biology (Basel). 2024 Apr 8;13(4):248. doi: 10.3390/biology13040248. Biology (Basel). 2024. PMID: 38666860 Free PMC article.
-
Fuzzy kernel evidence Random Forest for identifying pseudouridine sites.Brief Bioinform. 2024 Mar 27;25(3):bbae169. doi: 10.1093/bib/bbae169. Brief Bioinform. 2024. PMID: 38622357 Free PMC article.
-
Interpretable Multi-Scale Deep Learning for RNA Methylation Analysis across Multiple Species.Int J Mol Sci. 2024 Mar 1;25(5):2869. doi: 10.3390/ijms25052869. Int J Mol Sci. 2024. PMID: 38474116 Free PMC article.
-
A CNN based m5c RNA methylation predictor.Sci Rep. 2023 Dec 11;13(1):21885. doi: 10.1038/s41598-023-48751-9. Sci Rep. 2023. PMID: 38081880 Free PMC article.
-
Evaluation and development of deep neural networks for RNA 5-Methyluridine classifications using autoBioSeqpy.Front Microbiol. 2023 May 18;14:1175925. doi: 10.3389/fmicb.2023.1175925. eCollection 2023. Front Microbiol. 2023. PMID: 37275146 Free PMC article.
References
-
- Charette M., Gray M.W. Pseudouridine in RNA: what, where, how, and why. IUBMB Life. 2000;49:341–351. - PubMed
-
- Davis D.R., Veltri C.A., Nielsen L. An RNA model system for investigation of pseudouridine stabilization of the codon-anticodon interaction in tRNALys, tRNAHis and tRNATyr. J. Biomol. Struct. Dyn. 1998;15:1121–1132. - PubMed
LinkOut - more resources
Full Text Sources
Miscellaneous