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. 2019 Aug:495:382-393.
doi: 10.1016/j.cca.2019.05.004. Epub 2019 May 10.

The VLDL receptor plays a key role in the metabolism of postprandial remnant lipoproteins

Katsuyuki Nakajima  1 , Yoshiharu Tokita  2 , Akira Tanaka  3 , Sadao Takahashi  4
Affiliations

The VLDL receptor plays a key role in the metabolism of postprandial remnant lipoproteins

Katsuyuki Nakajima et al. Clin Chim Acta. 2019 Aug.

Abstract

A new concept to account for the process of postprandial remnant lipoprotein metabolism is proposed based on the characteristics of lipoprotein particles and their receptors. The characteristics of remnant lipoprotein (RLP) were investigated using an immuno-separation method. The majority of the postprandial lipoproteins increased after fat intake was shown to be VLDL remnants, not chylomicron (CM) remnants, based on the significantly high ratio of apoB100/apoB48 in the RLP and the high degree of similarity in the particle size of the apoB48 and apoB100 carrying lipoproteins, which fluctuate in parallel during a 6 h period after fat intake. The VLDL receptor was discovered as a receptor for TG-rich lipoprotein metabolism and is located in peripheral tissues such as skeletal muscle, adipose tissue, etc., but not in the liver. Postprandial VLDL particles are strongly bound and internalized into cells expressing the VLDL receptor. Ligands that bind to VLDL receptor, such as LPL and Lp(a), present in RLP. The presence of various specific ligands in VLDL remnants may enhance the capacity for binding to the VLDL receptor, which play the role primarily for energy delivery to the peripheral tissues, but is also a causal factor in atherogenic diseases when excessively and/or continuously remained in plasma.

Keywords: Adiponectin; ApoE; Chylomicron (CM) remnants; Fat load; Lipoprotein lipase (LPL); Low density lipoprotein (LDL) receptor; Lp(a); Metallothionein (I/II); PCSK9; Postprandial lipoproteins; Remnant lipoproteins (RLP); VLDL remnants; Very low density lipoprotein (VLDL) receptor.

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