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Review
. 2019 May 3:10:912.
doi: 10.3389/fmicb.2019.00912. eCollection 2019.

Anti-infective Properties of the Golden Spice Curcumin

Dimas Praditya  1   2   3 , Lisa Kirchhoff  4 , Janina Brüning  1 , Heni Rachmawati  5   6 , Joerg Steinmann  4   7 , Eike Steinmann  1
Affiliations
Review

Anti-infective Properties of the Golden Spice Curcumin

Dimas Praditya et al. Front Microbiol. .

Abstract

The search for novel anti-infectives is one of the most important challenges in natural product research, as diseases caused by bacteria, viruses, and fungi are influencing the human society all over the world. Natural compounds are a continuing source of novel anti-infectives. Accordingly, curcumin, has been used for centuries in Asian traditional medicine to treat various disorders. Numerous studies have shown that curcumin possesses a wide spectrum of biological and pharmacological properties, acting, for example, as anti-inflammatory, anti-angiogenic and anti-neoplastic, while no toxicity is associated with the compound. Recently, curcumin's antiviral and antibacterial activity was investigated, and it was shown to act against various important human pathogens like the influenza virus, hepatitis C virus, HIV and strains of Staphylococcus, Streptococcus, and Pseudomonas. Despite the potency, curcumin has not yet been approved as a therapeutic antiviral agent. This review summarizes the current knowledge and future perspectives of the antiviral, antibacterial, and antifungal effects of curcumin.

Keywords: anti-infective properties; bacteria; curcumin; fungi; natural products; nutraceutical; virus.

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Figures

FIGURE 1
FIGURE 1
Chemical structure of curcumin.
FIGURE 2
FIGURE 2
Nanocarrier systems encapsulating curcumin. Different nanoformulation strategies have been reported to improve the bioavailability and therapeutic efficacy of curcumin based on their chemical composition.
See this image and copyright information in PMC

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