Adjuvant drug-assisted bone healing: Part II - Modulation of angiogenesis
- PMID: 31177206
- DOI: 10.3233/CH-199103
Adjuvant drug-assisted bone healing: Part II - Modulation of angiogenesis
Abstract
The treatment of critical-size bone defects following complicated fractures, infections or tumor resections is a major challenge. The same applies to fractures in patients with impaired bone healing due to systemic inflammatory and metabolic diseases. Despite considerable progress in development and establishment of new surgical techniques, design of bone graft substitutes and imaging techniques, these scenarios still represent unresolved clinical problems. However, the development of new active substances offers novel potential solutions for these issues. This work discusses therapeutic approaches that influence angiogenesis or hypoxic situations in healing bone and surrounding tissue. In particular, literature on sphingosine-1-phosphate receptor modulators and nitric oxide (NO•) donors, including bi-functional (hybrid) compounds like NO•-releasing cyclooxygenase-2 inhibitors, was critically reviewed with regard to their local and systemic mode of action.
Keywords: Critical-size bone defects; neovascularization; nitric oxide donors; signaling; small molecules; sphingosine-1-phosphate receptor.
Similar articles
-
Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches.Pharmaceutics. 2020 May 6;12(5):428. doi: 10.3390/pharmaceutics12050428. Pharmaceutics. 2020. PMID: 32384753 Free PMC article. Review.
-
Adjuvant drug-assisted bone healing: Part III - Further strategies for local and systemic modulation.Clin Hemorheol Microcirc. 2019;73(3):439-488. doi: 10.3233/CH-199104. Clin Hemorheol Microcirc. 2019. PMID: 31177207
-
Adjuvant drug-assisted bone healing: Part I - Modulation of inflammation.Clin Hemorheol Microcirc. 2019;73(3):381-408. doi: 10.3233/CH-199102. Clin Hemorheol Microcirc. 2019. PMID: 31177205
-
Bone regeneration with active angiogenesis by basic fibroblast growth factor gene transfected mesenchymal stem cells seeded on porous beta-TCP ceramic scaffolds.Biomed Mater. 2006 Sep;1(3):93-9. doi: 10.1088/1748-6041/1/3/001. Epub 2006 Jun 5. Biomed Mater. 2006. PMID: 18458388
-
Role of nitric oxide in the modulation of angiogenesis.Curr Pharm Des. 2003;9(7):521-30. doi: 10.2174/1381612033391405. Curr Pharm Des. 2003. PMID: 12570800 Review.
Cited by
-
Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches.Pharmaceutics. 2020 May 6;12(5):428. doi: 10.3390/pharmaceutics12050428. Pharmaceutics. 2020. PMID: 32384753 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials