Subchondral bone remodelling in osteoarthritis
- PMID: 31210964
- PMCID: PMC6549114
- DOI: 10.1302/2058-5241.4.180102
Subchondral bone remodelling in osteoarthritis
Abstract
Subchondral bone remodelling is an integral part of osteoarthritis and involves the development of subchondral sclerosis seen on plain imaging, along with osteophyte formation.The development of these changes is due to persistent abnormal mechanical stresses which create a cellular and biomolecular response to microfractures in the subchondral bone and osteochondral junction.An early sign is bone marrow lesions seen on MRI scanning. Healing can occur at this stage by correcting the abnormal loads. Persistence leads to what is thought to be a delayed union or nonunion response by the bone.Microfractures of the osteochondral junction, coupled with articular cartilage fissuring and loss, allows synovial fluid to penetrate the subchondral bone along with cytokines and other molecules reacting with the bone cells to increase the pathological effects.This review gives an overview of the current thoughts on subchondral bone remodelling in osteoarthritis that is aimed at orthopaedic surgeons to help in the understanding of the pathogenesis of osteoarthritis and the role of surgical management. Cite this article: EFORT Open Rev 2019;4 DOI: 10.1302/2058-5241.4.180102.
Keywords: bone remodelling; osteoarthritis; subchondral.
Conflict of interest statement
ICMJE Conflict of interest statement: The author reports royalties from Corin/Tornier, outside the submitted work.
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References
-
- Weber A, Chan PMB, Wen C. Do immune cells lead the way in subchondral bone disturbance in osteoarthritis? Prog Biophys Mol Biol 2017. December 22; 10.1016/j.pbiomolbio.2017.12.004. [Epub ahead of print] - PubMed
-
- Dobson GP, Letson HL, Grant A, et al. Defining the osteoarthritis patient: back to the future. Osteoarthritis Cartilage 2018;26:1003-1007. - PubMed
-
- Loef M, van Beest S, Kroon FPB, et al. Comparison of histological and morphometrical changes underlying subchondral bone abnormalities in inflammatory and degenerative musculoskeletal disorders: a systematic review. Osteoarthritis Cartilage 2018;26:992-1002. - PubMed
-
- Muratovic D, Findlay DM, Cicuttini FM, et al. Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis. Bone 2018;108:193-201. - PubMed
-
- Suri S, Walsh DA. Osteochondral alterations in osteoarthritis. Bone 2012;51:204-211. - PubMed
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