Macrophages and Metabolism in the Tumor Microenvironment

doi:10.1016/j.cmet.2019.06.001

Review

. 2019 Jul 2;30(1):36-50.

doi: 10.1016/j.cmet.2019.06.001.

Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale¹, Gwenola Manic², Lisa M Coussens³, Guido Kroemer⁴, Lorenzo Galluzzi⁵

Affiliations

¹ Department of Biology, University of Rome "Tor Vergata", Rome, Italy; Italian Institute for Genomic Medicine (IIGM), Turin, Italy; Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Italy.
² IRCSS - Regina Elena National Cancer Institute, Rome, Italy.
³ Department of Cell Development & Cancer Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
⁴ Université Paris Descartes, Paris, France; Université Pierre et Marie Curie, Paris, France; Équipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; INSERM, U1138, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou, China; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden. Electronic address: kroemer@orange.fr.
⁵ Université Paris Descartes, Paris, France; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: deadoc80@gmail.com.

PMID: 31269428
DOI: 10.1016/j.cmet.2019.06.001

Free article

Review

Macrophages and Metabolism in the Tumor Microenvironment

Ilio Vitale et al. Cell Metab. 2019.

Free article

. 2019 Jul 2;30(1):36-50.

doi: 10.1016/j.cmet.2019.06.001.

Authors

Ilio Vitale¹, Gwenola Manic², Lisa M Coussens³, Guido Kroemer⁴, Lorenzo Galluzzi⁵

Affiliations

¹ Department of Biology, University of Rome "Tor Vergata", Rome, Italy; Italian Institute for Genomic Medicine (IIGM), Turin, Italy; Candiolo Cancer Institute - FPO, IRCCS, Candiolo, Italy.
² IRCSS - Regina Elena National Cancer Institute, Rome, Italy.
³ Department of Cell Development & Cancer Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR, USA.
⁴ Université Paris Descartes, Paris, France; Université Pierre et Marie Curie, Paris, France; Équipe 11 labellisée Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris, France; INSERM, U1138, Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy Cancer Campus, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Suzhou Institute for Systems Medicine, Chinese Academy of Sciences, Suzhou, China; Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden. Electronic address: kroemer@orange.fr.
⁵ Université Paris Descartes, Paris, France; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA. Electronic address: deadoc80@gmail.com.

PMID: 31269428
DOI: 10.1016/j.cmet.2019.06.001

Abstract

Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell population of the tumor microenvironment (TME) that can account for up to 50% of some solid neoplasms. Most often, TAMs support disease progression and resistance to therapy by providing malignant cells with trophic and nutritional support. However, TAMs can mediate antineoplastic effects, especially in response to pharmacological agents that boost their phagocytic and oxidative functions. Thus, TAMs and their impact on the overall metabolic profile of the TME have a major influence on tumor progression and resistance to therapy, de facto constituting promising targets for the development of novel anticancer agents. Here, we discuss the metabolic circuitries whereby TAMs condition the TME to support tumor growth and how such pathways can be therapeutically targeted.

Keywords: fatty acid oxidation; glycolysis; hypoxia; immunosuppressive metabolites; immunotherapy; oxidative phosphorylation.

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Macrophages and Metabolism in the Tumor Microenvironment

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Macrophages and Metabolism in the Tumor Microenvironment

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