Translation of genome to glycome: role of the Golgi apparatus
- PMID: 31330561
- DOI: 10.1002/1873-3468.13541
Translation of genome to glycome: role of the Golgi apparatus
Abstract
Glycans are one of the four biopolymers of the cell and they play important roles in cellular and organismal physiology. They consist of both linear and branched structures and are synthesized in a nontemplated manner in the secretory pathway of mammalian cells with the Golgi apparatus playing a key role in the process. In spite of the absence of a template, the glycans synthesized by a cell are not a random collection of possible glycan structures but a distribution of specific glycans in defined quantities that is unique to each cell type (Cell type here refers to distinct cell forms present in an organism that can be distinguished based on morphological, phenotypic and/or molecular criteria.) While information to produce cell type-specific glycans is encoded in the genome, how this information is translated into cell type-specific glycome (Glycome refers to the quantitative distribution of all glycan structures present in a given cell type.) is not completely understood. We summarize here the factors that are known to influence the fidelity of glycan biosynthesis and integrate them into known glycosylation pathways so as to rationalize the translation of genetic information to cell type-specific glycome.
Keywords: Golgi apparatus; glycosylation; glycosylation modeling.
© 2019 Federation of European Biochemical Societies.
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References
-
- Varki A (2017) Biological roles of glycans. Glycobiology 27, 3-49.
-
- Moremen KW, Tiemeyer M and Nairn AV (2012) Vertebrate protein glycosylation: diversity, synthesis and function. Nat Rev Mol Cell Biol 13, 448-462.
-
- Stanley P (2011) Golgi glycosylation. Cold Spring Harb Perspect Biol 3, a005199.
-
- Rudd P, Karlsson NG, Khoo K-H and Packer NH (2017) Glycomics and glycoproteomics. In Essentials of Glycobiology (Varki A, ed.), 3-7. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
-
- Roth J (1996) Protein glycosylation in the endoplasmic reticulum and the Golgi apparatus and cell type-specificity of cell surface glycoconjugate expression: analysis by the protein A-gold and lectin-gold techniques. Histochem Cell Biol 106, 79-92.
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