Role of Personalized Nutrition in Chronic-Degenerative Diseases

doi:10.3390/nu11081707

Review

. 2019 Jul 24;11(8):1707.

doi: 10.3390/nu11081707.

Role of Personalized Nutrition in Chronic-Degenerative Diseases

Affiliations

¹ Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
² Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. paola.gualtieri@uniroma2.it.
³ School of Specialization in Food Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
⁴ PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
⁵ UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.
⁶ Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
⁷ Division of Cardiology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
⁸ Department of Medical and Surgical Sciences, University of Magna Græcia, Viale Europa, Germaneto, 88100 Catanzaro, Italy.
⁹ Institute of Molecular Bioimaging and Physiology, National Research Council, Organizational Support Unit of Germaneto, University "Magna Graecia" of Catanzaro, Campus "Salvatore Venuta", 88100 Catanzaro, Italy.

PMID: 31344895
PMCID: PMC6723746
DOI: 10.3390/nu11081707

Review

Role of Personalized Nutrition in Chronic-Degenerative Diseases

Laura Di Renzo et al. Nutrients. 2019.

. 2019 Jul 24;11(8):1707.

doi: 10.3390/nu11081707.

Authors

Affiliations

¹ Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
² Section of Clinical Nutrition and Nutrigenomic, Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. paola.gualtieri@uniroma2.it.
³ School of Specialization in Food Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
⁴ PhD School of Applied Medical-Surgical Sciences, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
⁵ UOC of Internal Medicine-Center of Hypertension and Nephrology Unit, Department of Systems Medicine, University of Rome Tor Vergata, via Montpellier 1, 00133 Rome, Italy.
⁶ Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
⁷ Division of Cardiology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.
⁸ Department of Medical and Surgical Sciences, University of Magna Græcia, Viale Europa, Germaneto, 88100 Catanzaro, Italy.
⁹ Institute of Molecular Bioimaging and Physiology, National Research Council, Organizational Support Unit of Germaneto, University "Magna Graecia" of Catanzaro, Campus "Salvatore Venuta", 88100 Catanzaro, Italy.

PMID: 31344895
PMCID: PMC6723746
DOI: 10.3390/nu11081707

Abstract

Human nutrition is a branch of medicine based on foods biochemical interactions with the human body. The phenotypic transition from health to disease status can be attributed to changes in genes and/or protein expression. For this reason, a new discipline has been developed called "-omic science". In this review, we analyzed the role of "-omics sciences" (nutrigenetics, nutrigenomics, proteomics and metabolomics) in the health status and as possible therapeutic tool in chronic degenerative diseases. In particular, we focused on the role of nutrigenetics and the relationship between eating habits, changes in the DNA sequence and the onset of nutrition-related diseases. Moreover, we examined nutrigenomics and the effect of nutrients on gene expression. We perused the role of proteomics and metabolomics in personalized nutrition. In this scenario, we analyzed also how dysbiosis of gut microbiota can influence the onset and progression of chronic degenerative diseases. Moreover, nutrients influencing and regulating gene activity, both directly and indirectly, paves the way for personalized nutrition that plays a key role in the prevention and treatment of chronic degenerative diseases.

Keywords: Mediterranean diet; epigenetic; gut microbiota; nutrigenetic; nutrigenomic; obesity; personalized nutrition.

PubMed Disclaimer

Conflict of interest statement

Authors declare not to have any conflicts of interest.

Figures

**Figure 1**
4P medicine, in the era of -omics sciences; to switch from an unhealthy condition of dysbiosis to a healthy condition of eusbiosis. 4P: Predictive, personalized, preventive and participatory; HUFAs: h-3 highly unsaturated fatty acids; PUFAs: polyunsaturated fatty acids.

**Figure 2**
Flow diagram of search strategy.

See this image and copyright information in PMC

Cited by

The Future of Obesity Management through Precision Nutrition: Putting the Individual at the Center.
Ulusoy-Gezer HG, Rakıcıoğlu N. Ulusoy-Gezer HG, et al. Curr Nutr Rep. 2024 May 28. doi: 10.1007/s13668-024-00550-y. Online ahead of print. Curr Nutr Rep. 2024. PMID: 38806863 Review.
Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients.
Noce A, Marrone G, Di Lauro M, Vita C, Montalto G, Giorgino G, Chiaramonte C, D'Agostini C, Bernardini S, Pieri M. Noce A, et al. Pharmaceuticals (Basel). 2024 Apr 5;17(4):463. doi: 10.3390/ph17040463. Pharmaceuticals (Basel). 2024. PMID: 38675423 Free PMC article.
Food science and COVID-19.
Lange KW. Lange KW. Food Sci Hum Wellness. 2021 Jan;10(1):1-5. doi: 10.1016/j.fshw.2020.08.005. Epub 2020 Sep 23. Food Sci Hum Wellness. 2021. PMID: 38620884 Free PMC article. Review.
Emerging Perspectives on the Set of Conditions That Lead to the Emergence of Metabolic Syndrome.
Tarcău BM, Vicaș LG, Filip L, Maghiar F, Șandor M, Pallag A, Jurca T, Mureșan ME, Marian E. Tarcău BM, et al. J Pers Med. 2023 Dec 26;14(1):32. doi: 10.3390/jpm14010032. J Pers Med. 2023. PMID: 38248733 Free PMC article. Review.
Dietary Epigenetic Modulators: Unravelling the Still-Controversial Benefits of miRNAs in Nutrition and Disease.
Martino E, D'Onofrio N, Balestrieri A, Colloca A, Anastasio C, Sardu C, Marfella R, Campanile G, Balestrieri ML. Martino E, et al. Nutrients. 2024 Jan 3;16(1):160. doi: 10.3390/nu16010160. Nutrients. 2024. PMID: 38201989 Free PMC article. Review.

See all "Cited by" articles

References

1. Bragazzi N.L. Situating Nutri-Ethics at the Junction of Nutrigenomics and Nutriproteomics in Postgenomics Medicine. Curr. Pharm. Pers. Med. 2013;11:162–166. doi: 10.2174/1875692111311020008. - DOI - PMC - PubMed
1. Virgili F., Perozzi G. How does Nutrigenomics impact human health? IUBMB Life. 2008;60:341–344. doi: 10.1002/iub.85. - DOI - PubMed
1. Wolffe A.P., Matzke M.A. Epigenetics: Regulation through repression. Science. 1999;286:481–486. doi: 10.1126/science.286.5439.481. - DOI - PubMed
1. Juma S., Imrhan V., Vijayagopal P., Prasad C. Prescribing personalized nutrition for cardiovascular health: Are we ready? J. Nutrigenet. Nutr. 2014;7:153–160. doi: 10.1159/000370213. - DOI - PubMed
1. Kang J.X. Nutritional problems and solutions for the modern health epidemic. J. Nutrigenet. Nutr. 2014;7:188–190. doi: 10.1159/000375471. - DOI - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- The Lens - Patent Citations

[1] Bragazzi N.L. Situating Nutri-Ethics at the Junction of Nutrigenomics and Nutriproteomics in Postgenomics Medicine. Curr. Pharm. Pers. Med. 2013;11:162–166. doi: 10.2174/1875692111311020008. - DOI - PMC - PubMed

[2] Bragazzi N.L. Situating Nutri-Ethics at the Junction of Nutrigenomics and Nutriproteomics in Postgenomics Medicine. Curr. Pharm. Pers. Med. 2013;11:162–166. doi: 10.2174/1875692111311020008. - DOI - PMC - PubMed

[3] Virgili F., Perozzi G. How does Nutrigenomics impact human health? IUBMB Life. 2008;60:341–344. doi: 10.1002/iub.85. - DOI - PubMed

[4] Virgili F., Perozzi G. How does Nutrigenomics impact human health? IUBMB Life. 2008;60:341–344. doi: 10.1002/iub.85. - DOI - PubMed

[5] Wolffe A.P., Matzke M.A. Epigenetics: Regulation through repression. Science. 1999;286:481–486. doi: 10.1126/science.286.5439.481. - DOI - PubMed

[6] Wolffe A.P., Matzke M.A. Epigenetics: Regulation through repression. Science. 1999;286:481–486. doi: 10.1126/science.286.5439.481. - DOI - PubMed

[7] Juma S., Imrhan V., Vijayagopal P., Prasad C. Prescribing personalized nutrition for cardiovascular health: Are we ready? J. Nutrigenet. Nutr. 2014;7:153–160. doi: 10.1159/000370213. - DOI - PubMed

[8] Juma S., Imrhan V., Vijayagopal P., Prasad C. Prescribing personalized nutrition for cardiovascular health: Are we ready? J. Nutrigenet. Nutr. 2014;7:153–160. doi: 10.1159/000370213. - DOI - PubMed

[9] Kang J.X. Nutritional problems and solutions for the modern health epidemic. J. Nutrigenet. Nutr. 2014;7:188–190. doi: 10.1159/000375471. - DOI - PubMed

[10] Kang J.X. Nutritional problems and solutions for the modern health epidemic. J. Nutrigenet. Nutr. 2014;7:188–190. doi: 10.1159/000375471. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Role of Personalized Nutrition in Chronic-Degenerative Diseases

Affiliations

Role of Personalized Nutrition in Chronic-Degenerative Diseases

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Abstract

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

LinkOut - more resources

Full Text Sources

Other Literature Sources