Melatonin Stability in Human Milk
- PMID: 31381362
- DOI: 10.1089/bfm.2019.0088
Melatonin Stability in Human Milk
Abstract
Introduction: Melatonin is an antioxidant, a circadian pacemaker, and an immune system stimulator. Studies have demonstrated beneficial effects of melatonin on various conditions in neonates. Melatonin is secreted in breast milk in circadian rhythm, but its half-life and stability in this medium and in real-life conditions of freezing and defrosting is unknown. The objective of this feasibility study was to evaluate stability of melatonin in breast milk after freezing and defrosting. Methods and Results: Breast milk samples of nocturnal milk and daytime milk were collected from 13 healthy breastfeeding mothers and were immediately frozen. Samples were defrosted in room temperature and were sampled for melatonin immediately and every hour for 4 hours and at 24 hours after defrosting. Melatonin levels were measured with Melatonin direct Saliva ELISA kit (IBL International).There was no statistically significant difference between levels at the different time points (p = 0.696). Melatonin levels in daytime milk were significantly lower than night-time levels (p = 0.028). Conclusion: Melatonin is stable in human milk for at least 4 hours after defrosting and even up to 24 hours. Further research of the therapeutic potential of night breast milk high in melatonin is needed.
Keywords: ELISA; breast milk; lactation; melatonin; neonate.
Similar articles
-
Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?Nutrients. 2024 May 8;16(10):1422. doi: 10.3390/nu16101422. Nutrients. 2024. PMID: 38794660 Free PMC article. Review.
-
Maternal Circadian Disruption from Shift Work and the Impact on the Concentration of Melatonin in Breast Milk.Breastfeed Med. 2024 Jan;19(1):33-39. doi: 10.1089/bfm.2023.0252. Epub 2023 Dec 27. Breastfeed Med. 2024. PMID: 38150529
-
Melatonin in Early Nutrition: Long-Term Effects on Cardiovascular System.Int J Mol Sci. 2021 Jun 24;22(13):6809. doi: 10.3390/ijms22136809. Int J Mol Sci. 2021. PMID: 34202781 Free PMC article. Review.
-
Variations in melatonin levels in preterm and term human breast milk during the first month after delivery.Sci Rep. 2019 Nov 29;9(1):17984. doi: 10.1038/s41598-019-54530-2. Sci Rep. 2019. PMID: 31784629 Free PMC article.
-
Melatonin Concentrations and Antioxidative Capacity of Human Breast Milk According to Gestational Age and the Time of Day.J Hum Lact. 2016 Nov;32(4):NP105-NP110. doi: 10.1177/0890334415625217. Epub 2016 Jul 10. J Hum Lact. 2016. PMID: 27121237
Cited by
-
Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?Nutrients. 2024 May 8;16(10):1422. doi: 10.3390/nu16101422. Nutrients. 2024. PMID: 38794660 Free PMC article. Review.
-
Drugs in Human Milk Part 1: Practical and Analytical Considerations in Measuring Drugs and Metabolites in Human Milk.Clin Pharmacokinet. 2024 May;63(5):561-588. doi: 10.1007/s40262-024-01374-3. Epub 2024 May 15. Clin Pharmacokinet. 2024. PMID: 38748090 Review.
-
Neuroprotective Natural Products' Regulatory Effects on Depression via Gut-Brain Axis Targeting Tryptophan.Nutrients. 2022 Aug 10;14(16):3270. doi: 10.3390/nu14163270. Nutrients. 2022. PMID: 36014776 Free PMC article. Review.
-
Melatonin use during pregnancy and lactation: A scoping review of human studies.Braz J Psychiatry. 2022 May-Jun;44(3):342-348. doi: 10.1590/1516-4446-2021-2156. Braz J Psychiatry. 2022. PMID: 34730672 Free PMC article. Review.
-
Maternal Melatonin Deficiency Leads to Endocrine Pathologies in Children in Early Ontogenesis.Int J Mol Sci. 2021 Feb 19;22(4):2058. doi: 10.3390/ijms22042058. Int J Mol Sci. 2021. PMID: 33669686 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources