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Review
. 2019 Oct;252(4-5):213-226.
doi: 10.1007/s00232-019-00087-0. Epub 2019 Aug 21.

Membrane Dynamics in Health and Disease: Impact on Cellular Signalling

Pranav Adhyapak  1 , Shobhna Kapoor  2
Affiliations
Review

Membrane Dynamics in Health and Disease: Impact on Cellular Signalling

Pranav Adhyapak et al. J Membr Biol. 2019 Oct.

Abstract

Biological membranes display a staggering complexity of lipids and proteins orchestrating cellular functions. Superior analytical tools coupled with numerous functional cellular screens have enabled us to query their role in cellular signalling, trafficking, guiding protein structure and function-all of which rely on the dynamic membrane lipid properties indispensable for proper cellular functions. Alteration of these has led to emergence of various pathological conditions, thus opening an area of lipid-centric therapeutic approaches. This perspective is a short summary of the dynamic properties of membranes essential for proper cellular functions, dictating both protein and lipid functions, and mis-regulated in diseases. Towards the end, we focus on some challenges lying ahead and potential means to tackle the same, mainly underscored by multi-disciplinary approaches.

Keywords: Lipid diffusion; Lipid domains; Lipid-protein interactions; Membrane lipid structure; Membrane-targeting drugs.

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