Potential exerkines for physical exercise-elicited pro-cognitive effects: Insight from clinical and animal research
- PMID: 31607361
- DOI: 10.1016/bs.irn.2019.06.002
Potential exerkines for physical exercise-elicited pro-cognitive effects: Insight from clinical and animal research
Abstract
A sedentary lifestyle is now known as a critical risk factor for accelerated aging-related neurodegenerative disorders. In contract, having regular physical exercise has opposite effects. Clinical findings have suggested that physical exercise can promote brain plasticity, particularly the hippocampus and the prefrontal cortex, that are important for learning and memory and mood regulations. However, the underlying mechanisms are still unclear. Animal studies reveal that the effects of physical exercise on promoting neuroplasticity could be mediated by different exerkines derived from the peripheral system and the brain itself. This book chapter summarizes the recent evidence from clinical and pre-clinical studies showing the emerging mediators for exercise-promoted brain health, including myokines secreted from skeletal muscles, adipokines from adipose tissues, and other factors secreted from the bone and liver.
Keywords: Aging; Alzheimer's disease; Dementia; Depression; Diabetes; Exerkines; Hippocampus; Neuroplasticity; Obesity; Physical exercise.
© 2019 Elsevier Inc. All rights reserved.
Similar articles
-
The role of exerkines on brain mitochondria: a mini-review.J Appl Physiol (1985). 2023 Jan 1;134(1):28-35. doi: 10.1152/japplphysiol.00565.2022. Epub 2022 Nov 23. J Appl Physiol (1985). 2023. PMID: 36417200 Free PMC article. Review.
-
Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity.Front Neuroendocrinol. 2022 Jul;66:100993. doi: 10.1016/j.yfrne.2022.100993. Epub 2022 Mar 11. Front Neuroendocrinol. 2022. PMID: 35283168 Review.
-
Exercise, spinogenesis and cognitive functions.Int Rev Neurobiol. 2019;147:323-360. doi: 10.1016/bs.irn.2019.07.005. Epub 2019 Aug 6. Int Rev Neurobiol. 2019. PMID: 31607360 Review.
-
Modulation of synaptic plasticity by exercise.Int Rev Neurobiol. 2019;147:295-322. doi: 10.1016/bs.irn.2019.07.002. Epub 2019 Aug 6. Int Rev Neurobiol. 2019. PMID: 31607359 Review.
-
Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function.Neuroscience. 2006 Jul 7;140(3):823-33. doi: 10.1016/j.neuroscience.2006.02.084. Epub 2006 May 2. Neuroscience. 2006. PMID: 16650607
Cited by
-
Hepatic kynurenic acid mediates phosphorylation of Nogo-A in the medial prefrontal cortex to regulate chronic stress-induced anxiety-like behaviors in mice.Acta Pharmacol Sin. 2024 May 29. doi: 10.1038/s41401-024-01302-y. Online ahead of print. Acta Pharmacol Sin. 2024. PMID: 38811774
-
Highlighting the idea of exerkines in the management of cancer patients with cachexia: novel insights and a critical review.BMC Cancer. 2023 Sep 20;23(1):889. doi: 10.1186/s12885-023-11391-3. BMC Cancer. 2023. PMID: 37730552 Free PMC article. Review.
-
Running from stress: a perspective on the potential benefits of exercise-induced small extracellular vesicles for individuals with major depressive disorder.Front Mol Biosci. 2023 Jun 15;10:1154872. doi: 10.3389/fmolb.2023.1154872. eCollection 2023. Front Mol Biosci. 2023. PMID: 37398548 Free PMC article. Review.
-
Precious but convenient means of prevention and treatment: physiological molecular mechanisms of interaction between exercise and motor factors and Alzheimer's disease.Front Physiol. 2023 Jun 8;14:1193031. doi: 10.3389/fphys.2023.1193031. eCollection 2023. Front Physiol. 2023. PMID: 37362440 Free PMC article. Review.
-
Exercise-Induced Fibroblast Growth Factor-21: A Systematic Review and Meta-Analysis.Int J Mol Sci. 2023 Apr 14;24(8):7284. doi: 10.3390/ijms24087284. Int J Mol Sci. 2023. PMID: 37108444 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical