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Review
. 2019 Dec;33(4):869-889.
doi: 10.1016/j.idc.2019.07.001.

Severe Acute Respiratory Syndrome: Historical, Epidemiologic, and Clinical Features

David S C Hui  1 , Alimuddin Zumla  2
Affiliations
Review

Severe Acute Respiratory Syndrome: Historical, Epidemiologic, and Clinical Features

David S C Hui et al. Infect Dis Clin North Am. 2019 Dec.

Abstract

Severe acute respiratory syndrome coronavirus (SARS-CoV), emerged from China and rapidly spread worldwide. Over 8098 people fell ill and 774 died before the epidemic ended in July 2003. Bats are likely an important reservoir for SARS-CoV. SARS-like CoVs have been detected in horseshoe bats and civet cats. The main mode of transmission of SARS-CoV is through inhalation of respiratory droplets. Faeco-oral transmission has been recorded. Strict infection control procedures with respiratory and contact precautions are essential. Fever and respiratory symptoms predominate, and diarrhea is common. Treatment involves supportive care. There are no specific antiviral treatments or vaccines available.

Keywords: Clinical; Coronavirus; Epidemic; Epidemiology; Prevention; SARS.

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Figures

Fig. 1
Fig. 1
Global distribution of SARS.
Fig. 2
Fig. 2
Chest radiograph of a patient showing opacities at the right lower zone and left mid and lower zones.
Fig. 3
Fig. 3
Chest tomography of another patient with ground-glass opacity at the anterolateral segment of the left lower lobe.
See this image and copyright information in PMC

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References

    1. Zhao Z., Zhang F., Xu M., et al. Description and clinical treatment of an early outbreak of severe acute respiratory syndrome (SARS) in Guangzhou, PR China. J Med Microbiol. 2003;52:715–720. - PubMed
    1. WHO List of blue print priority diseases. https://www.who.int/blueprint/priority-diseases/en/ Available at: Accessed January7, 2019.
    1. Tsang K.W., Ho P.L., Ooi G.C., et al. A cluster of cases of severe acute respiratory syndrome in Hong Kong. N Engl J Med. 2003;348:1977–1985. - PubMed
    1. Peiris J.S., Lai S.T., Poon L.L., et al. SARS study group Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet. 2003;361(9366):1319–1325. - PMC - PubMed
    1. WHO Summary of probable SARS cases with onset of illness from 1 November to 31 July 2003. 2003. http://www.who.int/csr/sars/country/table2004_04_21/en/ Available at: Accessed January 10, 2016.

MeSH terms

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