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. 2019 Dec 10;3(23):4131-4135.
doi: 10.1182/bloodadvances.2019000898.

Resolution of secondary hemophagocytic lymphohistiocytosis after treatment with the JAK1/2 inhibitor ruxolitinib

Scott R Goldsmith  1   2 , Sana Saif Ur Rehman  2 , Cara L Shirai  3 , Kiran Vij  1   3 , John F DiPersio  1
Affiliations

Resolution of secondary hemophagocytic lymphohistiocytosis after treatment with the JAK1/2 inhibitor ruxolitinib

Scott R Goldsmith et al. Blood Adv. .

Abstract

  1. Ruxolitinib was an effective salvage therapy for relapsed/refractory secondary hemophagocytic lymphohistiocytosis.

  2. Prolonged maintenance with a ruxolitinib taper obviated the need for intensive chemotherapy or allogeneic transplant in secondary HLH.

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Conflict of interest statement

Conflict-of-interest disclosure: J.F.D. reports honorarium from Incyte Corp. The remaining authors declare no competing financial interests.

Figures

Figure 1.
Figure 1.
Effect of ruxolitinib on laboratory parameters (to last follow-up) and fevers (during hospitalization) with time course of therapy administration in the treatment of relapsed/refractory secondary HLH. Patient 1 (A-B) and patient 2 (C-D). CRP, C-reactive protein; Tmax, maximum temperature.
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