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Review
. 2020 Mar:502:139-147.
doi: 10.1016/j.cca.2019.12.016. Epub 2019 Dec 23.

Autophagy, an important therapeutic target for pulmonary fibrosis diseases

Hong Zhao  1 , Yiqun Wang  2 , Tingting Qiu  1 , Wei Liu  3 , Pingbo Yao  4
Affiliations
Review

Autophagy, an important therapeutic target for pulmonary fibrosis diseases

Hong Zhao et al. Clin Chim Acta. 2020 Mar.

Abstract

As an evolutionarily conserved intracellular degradation pathway, autophagy is essential to cellular homeostasis. Several studies have demonstrated that autophagy showed an important effect on some pulmonary fibrosis diseases, including idiopathic pulmonary fibrosis (IPF), cystic fibrosis lung disease, silicosis and smoking-induced pulmonary fibrosis. For example, autophagy mitigates the pathological progression of IPF by regulating the apoptosis of fibroblasts and the senescence of alveolar epithelial cells. In addition, autophagy ameliorates cystic fibrosis lung disease via rescuing transmembrane conductance regulators (CFTRs) to the plasma membrane. Furthermore, autophagy alleviates the silica-induced pulmonary fibrosis by decreasing apoptosis of alveolar epithelial cells in silicosis. However, excessive macrophage autophagy aggravates the pathogenesis of silicosis fibrosis by promoting the proliferation and migration of lung fibroblasts in silicosis. Autophagy is also involved in smoking-induced pulmonary fibrosis, coal workers' pneumoconiosis, ionizing radiation-mediated pulmonary fibrosis and heavy metal nanoparticle-mediated pulmonary fibrosis. In this review, the role and signalling mechanisms of autophagy in the progression of pulmonary fibrosis diseases have been systematically analysed. It has provided a new insight into the therapeutic potential associated with autophagy in pulmonary fibrosis diseases. In conclusion, the targeting of autophagy might prove to be a prospective avenue for the therapeutic intervention of pulmonary fibrosis diseases.

Keywords: Autophagy; Cystic fibrosis lung disease; Idiopathic pulmonary fibrosis (IPF); Silicosis; Smoking-induced pulmonary fibrosis.

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Conflict of interest statement

Declaration of Competing Interest The authors declared that there is no conflict of interest.

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