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. 2020 Mar:137:111138.
doi: 10.1016/j.fct.2020.111138. Epub 2020 Jan 22.

Cardiomyopathy induced by T-2 toxin in rats

Vesna Jaćević  1 , Qinghua Wu  2 , Eugenie Nepovimova  3 , Kamil Kuča  4
Affiliations

Cardiomyopathy induced by T-2 toxin in rats

Vesna Jaćević et al. Food Chem Toxicol. 2020 Mar.

Abstract

T-2 toxin, A trichothecenes mycotoxin, is immunotoxic to animals and humans. Although it is highly cardiotoxic, the pathogenesis of cardiomyopathy caused by T-2 toxin is not entirely clear. Hence, in our research, cardiomyopathy was induced by a single injection of T-2 mycotoxin (0.23 mg/kg s.c., 1 LD50) to Wistar rats. The cardiac tissue was carefully examinated by using basic histopathology, semiquantitative (tissue grading score scales) and imaging (a total number of mast cells - MCs) analyses on days 1, 7, 14, 21, 28 and 60 of the study. The most intensive myocardial alterations (cardiac damage score, CDS = 4.20-4.40), irregular glycogen distribution (glycogen distribution score, GDS = 4.07-4.17), haemorrhagic foci (vascular damage score, VDS = 4.57-4.90), diffuse accumulation and degranulation of MCs were observed on day 28 and 60 after treatment (p < 0.001 vs. control and 1st T-2-toxin-treated group, respectively). Besides, statistically significant positive correlations were obtained regarding myocardial injury, glycogen distribution and intensity of haemorrhage, and a negative correlation was found in the case of MCs. Obtained results are essential and crucial for further in vivo experimental studies, including the development of medications able to reduce T-2 toxin-induced cardiotoxicity.

Keywords: Analyses; Cardiotoxicity; Histopathology; Rats; Semiquantitative; T-2 toxin.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing for financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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