The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials
- PMID: 32016124
- PMCID: PMC6988671
- DOI: 10.1155/2020/8765139
The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials
Erratum in
-
Corrigendum to "The Threshold of the Severity of Diabetic Retinopathy below Which Intensive Glycemic Control Is Beneficial in Diabetic Patients: Estimation Using Data from Large Randomized Clinical Trials" by Yuqi Liu,Juan Li, Jinfang Ma, Nanwei Tong.J Diabetes Res. 2020 Jun 25;2020:5498528. doi: 10.1155/2020/5498528. eCollection 2020. J Diabetes Res. 2020. PMID: 32685559 Free PMC article.
Abstract
Intensive glucose therapy can protect the retina of individuals with diabetes, but it is unknown if it provides the same protection to patients with different severity of diabetic retinopathy (DR). We finally included DR-related studies involving intensive glucose control with large sample size and long follow-up time, including five large and high-quality randomized clinical trials (RCTs): DCCT, UKPDS, ACCORD, AdRem, and VADT. With DCCT as a reference, we supposed a DR severity threshold that is verified by other RCTs then. We found that individuals who have DR lesions that are equivalent to or less severe than moderate NPDR achieve benefits for the retina by intensive glycemic control. However, these are realized only if the HbA1c in type 1 or type 2 diabetic patients is reduced at least by 0.8% versus the control group or it is reduced to <7% and >3 years of intensive glucose control is required. If the severity of DR lesions is worse than moderate NPDR, intensive glycemic control may not bring benefits.
Copyright © 2020 Yuqi Liu et al.
Conflict of interest statement
The authors declare that they have no conflict of interest.
Similar articles
-
Metabolic memory: Evolving concepts.J Diabetes. 2018 Mar;10(3):186-187. doi: 10.1111/1753-0407.12622. Epub 2017 Dec 11. J Diabetes. 2018. PMID: 29091343
-
Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: a meta-analysis of individual participant data from randomised controlled trials.Lancet Diabetes Endocrinol. 2017 Jun;5(6):431-437. doi: 10.1016/S2213-8587(17)30104-3. Epub 2017 Mar 30. Lancet Diabetes Endocrinol. 2017. PMID: 28365411
-
Association of Time in Range, as Assessed by Continuous Glucose Monitoring, With Diabetic Retinopathy in Type 2 Diabetes.Diabetes Care. 2018 Nov;41(11):2370-2376. doi: 10.2337/dc18-1131. Epub 2018 Sep 10. Diabetes Care. 2018. PMID: 30201847
-
Prevention and treatment of diabetic retinopathy: evidence from large, randomized trials. The emerging role of fenofibrate.Rev Recent Clin Trials. 2012 Feb;7(1):71-80. doi: 10.2174/157488712799363299. Rev Recent Clin Trials. 2012. PMID: 21864248 Review.
-
Metabolic control and diabetic retinopathy.Curr Diabetes Rev. 2009 Feb;5(1):3-7. doi: 10.2174/157339909787314176. Curr Diabetes Rev. 2009. PMID: 19199891 Review.
Cited by
-
Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy.Cochrane Database Syst Rev. 2023 Feb 22;2(2):CD013775. doi: 10.1002/14651858.CD013775.pub2. Cochrane Database Syst Rev. 2023. PMID: 36815723 Free PMC article. Review.
-
Recent developments on computer aided systems for diagnosis of diabetic retinopathy: a review.Multimed Tools Appl. 2023;82(10):14471-14525. doi: 10.1007/s11042-022-13841-9. Epub 2022 Sep 24. Multimed Tools Appl. 2023. PMID: 36185322 Free PMC article.
-
Natural History of Diabetic Retinopathy Through Retrospective Analysis in Type 2 Diabetic Patients-An Exploratory Study.Front Public Health. 2021 Nov 29;9:791378. doi: 10.3389/fpubh.2021.791378. eCollection 2021. Front Public Health. 2021. PMID: 34912774 Free PMC article.
-
Lysophosphatidylcholine Offsets the Protective Effects of Bone Marrow Mesenchymal Stem Cells on Inflammatory Response and Oxidative Stress Injury of Retinal Endothelial Cells via TLR4/NF-κB Signaling.J Immunol Res. 2021 Oct 14;2021:2389029. doi: 10.1155/2021/2389029. eCollection 2021. J Immunol Res. 2021. PMID: 34692851 Free PMC article.
-
SERPINH1, Targeted by miR-29b, Modulated Proliferation and Migration of Human Retinal Endothelial Cells Under High Glucose Conditions.Diabetes Metab Syndr Obes. 2021 Aug 4;14:3471-3483. doi: 10.2147/DMSO.S307771. eCollection 2021. Diabetes Metab Syndr Obes. 2021. PMID: 34377003 Free PMC article.
References
-
- Panel. AAoORV. Preferred Practice Pattern® Guidelines. Diabetic Retinopathy. 2016, https://www.aao.org/ppp.
-
- The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The New England Journal of Medicine. 1993;329(14):977–986. doi: 10.1056/nejm199309303291401. - DOI - PubMed
-
- UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33) The Lancet. 1998;352(9131):837–853. doi: 10.1016/s0140-6736(98)07019-6. - DOI - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical