The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms
- PMID: 32075282
- PMCID: PMC7074263
- DOI: 10.3390/md18020114
The Biological and Chemical Diversity of Tetramic Acid Compounds from Marine-Derived Microorganisms
Abstract
Tetramic acid (pyrrolidine-2,4-dione) compounds, isolated from a variety of marine and terrestrial organisms, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities. In the past decade, marine-derived microorganisms have become great repositories of novel tetramic acids. Here, we discuss the biological activities of 277 tetramic acids of eight classifications (simple 3-acyl tetramic acids, 3-oligoenoyltetramic acids, 3-decalinoyltetramic acid, 3-spirotetramic acids, macrocyclic tetramic acids, N-acylated tetramic acids, α-cyclopiazonic acid-type tetramic acids, and other tetramic acids) from marine-derived microbes, including fungi, actinobacteria, bacteria, and cyanobacteria, as reported in 195 research studies up to 2019.
Keywords: bioactivity; marine natural product; marine-derived microorganisms; tetramic acid.
Conflict of interest statement
The authors declare no conflicts of interest.
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