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. 2020:2118:111-120.
doi: 10.1007/978-1-0716-0319-2_8.

Formulation and Characterization of Antithrombin Perfluorocarbon Nanoparticles

Alexander J Wilson  1 , Qingyu Zhou  2 , Ian Vargas  1 , Rohun Palekar  3 , Ryan Grabau  1 , Hua Pan  1 , Samuel A Wickline  4
Affiliations

Formulation and Characterization of Antithrombin Perfluorocarbon Nanoparticles

Alexander J Wilson et al. Methods Mol Biol. 2020.

Abstract

Thrombin, a major protein involved in the clotting cascade by the conversion of inactive fibrinogen to fibrin, plays a crucial role in the development of thrombosis. Antithrombin nanoparticles enable site-specific anticoagulation without increasing bleeding risk. Here we outline the process of making and the characterization of bivalirudin and D-phenylalanyl-L-prolyl-L-arginyl-chloromethyl ketone (PPACK) nanoparticles. Additionally, the characterization of these nanoparticles, including particle size, zeta potential, and quantification of PPACK/bivalirudin loading, is also described.

Keywords: Anticoagulation; Bivalirudin; PPACK; Perfluorocarbon nanoparticles; Thrombin.

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