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Review
. 2020 Apr 28;14(4):3822-3835.
doi: 10.1021/acsnano.0c02624. Epub 2020 Mar 30.

Diagnosing COVID-19: The Disease and Tools for Detection

Buddhisha Udugama  1   2 , Pranav Kadhiresan  1   2 , Hannah N Kozlowski  1   2 , Ayden Malekjahani  1   2 , Matthew Osborne  1   2 , Vanessa Y C Li  1   2 , Hongmin Chen  1   2 , Samira Mubareka  3   4 , Jonathan B Gubbay  3   5   6 , Warren C W Chan  1   2   7   8
Affiliations
Review

Diagnosing COVID-19: The Disease and Tools for Detection

Buddhisha Udugama et al. ACS Nano. .

Abstract

COVID-19 has spread globally since its discovery in Hubei province, China in December 2019. A combination of computed tomography imaging, whole genome sequencing, and electron microscopy were initially used to screen and identify SARS-CoV-2, the viral etiology of COVID-19. The aim of this review article is to inform the audience of diagnostic and surveillance technologies for SARS-CoV-2 and their performance characteristics. We describe point-of-care diagnostics that are on the horizon and encourage academics to advance their technologies beyond conception. Developing plug-and-play diagnostics to manage the SARS-CoV-2 outbreak would be useful in preventing future epidemics.

Keywords: COVID-19; PCR; SARS-CoV-2; diagnostics; pandemic; surveillance.

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