Pulsed Electromagnetic Field Versus Whole Body Vibration on Cartilage and Subchondral Trabecular Bone in Mice With Knee Osteoarthritis
- PMID: 32277513
- DOI: 10.1002/bem.22263
Pulsed Electromagnetic Field Versus Whole Body Vibration on Cartilage and Subchondral Trabecular Bone in Mice With Knee Osteoarthritis
Abstract
Pulsed electromagnetic field (PEMF) and whole body vibration (WBV) interventions are expected to be important strategies for management of osteoarthritis (OA). The aim of the study was to investigate the comparative effectiveness of PEMF versus WBV on cartilage and subchondral trabecular bone in mice with knee OA (KOA) induced by surgical destabilization of the medial meniscus (DMM). Forty 12-week-old male C57/BL mice were randomly divided into four groups (n = 10): Control, OA, PEMF, and WBV. OA was induced (OA, PEMF, and WBV groups) by surgical DMM of right knee joint. Mice in PEMF group received 1 h/day PEMF exposure with 75 Hz, 1.6 mT for 4 weeks, and the WBV group was exposed to WBV for 20 min/day with 5 Hz, 4 mm, 0.3 g peak acceleration for 4 weeks. Micro-computed tomography (micro-CT), histology, and immunohistochemistry analyses were performed to evaluate the changes in cartilage and microstructure of trabecular bone. The bone volume fraction (BV/TV), trabecular thickness (Tb.Th), and trabecular number (Tb.N) increased, and bone surface/bone volume (BS/BV) decreased by micro-CT analysis in PEMF and WBV groups. The Osteoarthritis Research Society International (OARSI) scores in PEMF and WBV groups were significantly lower than in the OA group. Immunohistochemical results showed that PEMF and WBV promoted expressions of Aggrecan, and inhibited expressions of IL-1β, ADAMTS4, and MMP13. Superior results are seen in PEMF group compared with WBV group. Both PEMF and WBV were effective, could delay cartilage degeneration and preserve subchondral trabecular bone microarchitecture, and PEMF was found to be superior to WBV. Bioelectromagnetics. 2020;41:298-307 © 2020 Bioelectromagnetics Society.
Keywords: cartilage; knee osteoarthritis; pulsed electromagnetic field; subchondral bone; whole body vibration.
© 2020 Bioelectromagnetics Society.
Similar articles
-
Low-frequency whole-body vibration can enhance cartilage degradation with slight changes in subchondral bone in mice with knee osteoarthritis and does not have any morphologic effect on normal joints.PLoS One. 2023 Aug 17;18(8):e0270074. doi: 10.1371/journal.pone.0270074. eCollection 2023. PLoS One. 2023. PMID: 37590222 Free PMC article.
-
Hemodynamic stress shapes subchondral bone in osteoarthritis: An emerging hypothesis.J Orthop Translat. 2021 Dec 30;32:85-90. doi: 10.1016/j.jot.2021.11.007. eCollection 2022 Jan. J Orthop Translat. 2021. PMID: 35070712 Free PMC article. Review.
-
Pulsed electromagnetic field improves subchondral bone microstructure in knee osteoarthritis rats through a Wnt/β-catenin signaling-associated mechanism.Bioelectromagnetics. 2018 Feb;39(2):89-97. doi: 10.1002/bem.22106. Epub 2017 Dec 18. Bioelectromagnetics. 2018. PMID: 29251361
-
Pulsed electromagnetic field at different stages of knee osteoarthritis in rats induced by low-dose monosodium iodoacetate: Effect on subchondral trabecular bone microarchitecture and cartilage degradation.Bioelectromagnetics. 2017 Apr;38(3):227-238. doi: 10.1002/bem.22028. Epub 2016 Dec 27. Bioelectromagnetics. 2017. PMID: 28026095
-
Effects of pulsed electromagnetic field on knee osteoarthritis: a systematic review.Rheumatology (Oxford). 2013 May;52(5):815-24. doi: 10.1093/rheumatology/kes063. Epub 2012 Apr 13. Rheumatology (Oxford). 2013. PMID: 22504115 Review.
Cited by
-
Low-frequency whole-body vibration can enhance cartilage degradation with slight changes in subchondral bone in mice with knee osteoarthritis and does not have any morphologic effect on normal joints.PLoS One. 2023 Aug 17;18(8):e0270074. doi: 10.1371/journal.pone.0270074. eCollection 2023. PLoS One. 2023. PMID: 37590222 Free PMC article.
-
[Effect of pulsed electromagnetic fields on mesenchymal stem cell-derived exosomes in inhibiting chondrocyte apoptosis].Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023 Feb 25;40(1):95-102. doi: 10.7507/1001-5515.202209053. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2023. PMID: 36854553 Free PMC article. Chinese.
-
Mechanical Loading Promotes the Migration of Endogenous Stem Cells and Chondrogenic Differentiation in a Mouse Model of Osteoarthritis.Calcif Tissue Int. 2023 Mar;112(3):363-376. doi: 10.1007/s00223-022-01052-1. Epub 2022 Dec 25. Calcif Tissue Int. 2023. PMID: 36566445
-
Hydrogel-hydroxyapatite-monomeric collagen type-I scaffold with low-frequency electromagnetic field treatment enhances osteochondral repair in rabbits.Stem Cell Res Ther. 2021 Nov 13;12(1):572. doi: 10.1186/s13287-021-02638-6. Stem Cell Res Ther. 2021. PMID: 34774092 Free PMC article.
References
REFERENCES
-
- Abdel-Aziem AA, Soliman ES, Mosaad DM, Draz AH. 2018. Effect of a physiotherapy rehabilitation program on knee osteoarthritis in patients with different pain intensities. J Phys Ther Sci 30:307-312.
-
- Albus U. 2012. Guide for the Care and Use of Laboratory Animals, eighth edition. Washington, DC: National Academies Press. pp 267-268.
-
- Bagnato GL, Miceli G, Marino N, Sciortino D, Bagnato GF. 2016. Pulsed electromagnetic fields in knee osteoarthritis: A double blind, placebo-controlled, randomized clinical trial. Rheumatology 55:755-762.
-
- Benazzo F, Cadossi M, Cavani F, Fini M, Giavaresi G, Setti S, Cadossi R, Giardino R. 2008. Cartilage repair with osteochondral autografts in sheep: Effect of biophysical stimulation with pulsed electromagnetic fields. J Orthop Res 26:631-642.
-
- Burr DB, Gallant MA. 2012. Bone remodelling in osteoarthritis. Nat Rev Rheumatol 8:665-673.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources