SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

doi:10.1016/j.cytogfr.2020.06.001

Review

. 2020 Aug:54:62-75.

doi: 10.1016/j.cytogfr.2020.06.001. Epub 2020 Jun 2.

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

Víctor J Costela-Ruiz¹, Rebeca Illescas-Montes¹, Jose M Puerta-Puerta², Concepción Ruiz³, Lucia Melguizo-Rodríguez¹

Affiliations

¹ Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016. Granada, Spain; Institute of Biosanitary Research, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012. Granada, Spain.
² Hematology & Hemotherapy Unit. Universitary Hospital Virgen de las Nieves, Granada, Spain.
³ Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016. Granada, Spain; Institute of Biosanitary Research, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012. Granada, Spain; Institute of Neuroscience, University of Granada, Centro de Investigación Biomédica (CIBM). Parque de Tecnológico de la Salud (PTS) Avda. del Conocimiento S/N, 18016, Armilla, Granada, Spain. Electronic address: crr@ugr.es.

PMID: 32513566
PMCID: PMC7265853
DOI: 10.1016/j.cytogfr.2020.06.001

Review

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

Víctor J Costela-Ruiz et al. Cytokine Growth Factor Rev. 2020 Aug.

. 2020 Aug:54:62-75.

doi: 10.1016/j.cytogfr.2020.06.001. Epub 2020 Jun 2.

Authors

Víctor J Costela-Ruiz¹, Rebeca Illescas-Montes¹, Jose M Puerta-Puerta², Concepción Ruiz³, Lucia Melguizo-Rodríguez¹

Affiliations

¹ Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016. Granada, Spain; Institute of Biosanitary Research, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012. Granada, Spain.
² Hematology & Hemotherapy Unit. Universitary Hospital Virgen de las Nieves, Granada, Spain.
³ Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustración 60, 18016. Granada, Spain; Institute of Biosanitary Research, ibs.Granada, C/ Doctor Azpitarte 4, 4ª planta, 18012. Granada, Spain; Institute of Neuroscience, University of Granada, Centro de Investigación Biomédica (CIBM). Parque de Tecnológico de la Salud (PTS) Avda. del Conocimiento S/N, 18016, Armilla, Granada, Spain. Electronic address: crr@ugr.es.

PMID: 32513566
PMCID: PMC7265853
DOI: 10.1016/j.cytogfr.2020.06.001

Abstract

COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.

Keywords: COVID-19; Chemokines; Cytokine storm; Growth factors; SARS-CoV-2.

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Conflict of interest statement

The authors declare no competing or financial interests.

Figures

**Fig. 1**
Cytokine storm and severity of the COVID-19 disease.

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References

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[1] Chen Y., Liu Q., Guo D. Emerging coronaviruses: genome structure, replication, and pathogenesis. J. Med. Virol. 2020;92:418–423. doi: 10.1002/jmv.25681. - DOI - PMC - PubMed

[2] Chen Y., Liu Q., Guo D. Emerging coronaviruses: genome structure, replication, and pathogenesis. J. Med. Virol. 2020;92:418–423. doi: 10.1002/jmv.25681. - DOI - PMC - PubMed

[3] Zhu N., Zhang D., Wang W., Li X., Yang B., Song J., Zhao X., Huang B., Shi W., Lu R., Niu P., Zhan F., Ma X., Wang D., Xu W., Wu G., Gao G.F., Tan W. China novel coronavirus investigating and research team, a novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733. doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed

[4] Zhu N., Zhang D., Wang W., Li X., Yang B., Song J., Zhao X., Huang B., Shi W., Lu R., Niu P., Zhan F., Ma X., Wang D., Xu W., Wu G., Gao G.F., Tan W. China novel coronavirus investigating and research team, a novel coronavirus from patients with pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733. doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed

[5] Guo Y.-R., Cao Q.-D., Hong Z.-S., Tan Y.-Y., Chen S.-D., Jin H.-J., Tan K.-S., Wang D.-Y., Yan Y. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil. Med. Res. 2020;7:11. doi: 10.1186/s40779-020-00240-0. - DOI - PMC - PubMed

[6] Guo Y.-R., Cao Q.-D., Hong Z.-S., Tan Y.-Y., Chen S.-D., Jin H.-J., Tan K.-S., Wang D.-Y., Yan Y. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil. Med. Res. 2020;7:11. doi: 10.1186/s40779-020-00240-0. - DOI - PMC - PubMed

[7] Sun P., Lu X., Xu C., Sun W., Pan B. Understanding of COVID-19 based on current evidence. J. Med. Virol. 2020 doi: 10.1002/jmv.25722. - DOI - PMC - PubMed

[8] Sun P., Lu X., Xu C., Sun W., Pan B. Understanding of COVID-19 based on current evidence. J. Med. Virol. 2020 doi: 10.1002/jmv.25722. - DOI - PMC - PubMed

[9] Ji W., Wang W., Zhao X., Zai J., Li X. Cross-species transmission of the newly identified coronavirus 2019-nCoV. J. Med. Virol. 2020;92:433–440. doi: 10.1002/jmv.25682. - DOI - PMC - PubMed

[10] Ji W., Wang W., Zhao X., Zai J., Li X. Cross-species transmission of the newly identified coronavirus 2019-nCoV. J. Med. Virol. 2020;92:433–440. doi: 10.1002/jmv.25682. - DOI - PMC - PubMed

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SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

Affiliations

SARS-CoV-2 infection: The role of cytokines in COVID-19 disease

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Conflict of interest statement

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