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Review
. 2020 Aug;10(4):171-186.
doi: 10.1007/s13659-020-00250-4. Epub 2020 Jun 11.

Natural Products as Potential Leads Against Coronaviruses: Could They be Encouraging Structural Models Against SARS-CoV-2?

Affiliations
Review

Natural Products as Potential Leads Against Coronaviruses: Could They be Encouraging Structural Models Against SARS-CoV-2?

Ilkay Erdogan Orhan et al. Nat Prod Bioprospect. 2020 Aug.

Abstract

New coronavirus referred to SARS-CoV-2 has caused a worldwide pandemic (COVID-19) declared by WHO. Coronavirus disease 2019 (COVID-19) is an infectious disease with severe acute respiratory syndrome caused by coronavirus-2 (SARS-CoV-2). SARS-CoV-2 is akin to SARS-CoV, which was the causative agent of severe acute respiratory syndrome (SARS) in 2002 as well as to that of Middle East respiratory syndrome (MERS) in 2012. SARS-CoV-2 has been revealed to belong to Coronaviridiae family as a member of β-coronaviruses. It has a positive-sense single-stranded RNA with the largest RNA genome. Since its genomic sequence has a notable similarity to that of SARS-CoV, antiviral drugs used to treat SARS and MERS are now being also applied for COVID-19 treatment. In order to combat SARS-CoV-2, many drug and vaccine development studies at experimental and clinical levels are currently conducted worldwide. In this sense, medicinal plants and the pure natural molecules isolated from plants have been reported to exhibit significant inhibitory antiviral activity against SARS-CoV and other types of coronaviruses. In the present review, plant extracts and natural molecules with the mentioned activity are discussed in order to give inspiration to researchers to take these molecules into consideration against SARS-CoV-2.

Keywords: Antiviral; Coronavirus; Medicinal plants; Natural products; SARS-CoV.

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Conflict of interest statement

The authors declare no conflict of interest, financial, and otherwise.

Figures

Fig. 1
Fig. 1
Chemical structures of some promising natural molecules
Fig. 1
Fig. 1
Chemical structures of some promising natural molecules
Fig. 1
Fig. 1
Chemical structures of some promising natural molecules

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