Gut microbiota: A target for heavy metal toxicity and a probiotic protective strategy

doi:10.1016/j.scitotenv.2020.140429

Review

. 2020 Nov 10:742:140429.

doi: 10.1016/j.scitotenv.2020.140429. Epub 2020 Jun 25.

Gut microbiota: A target for heavy metal toxicity and a probiotic protective strategy

Hui Duan¹, Leilei Yu², Fengwei Tian³, Qixiao Zhai³, Liuping Fan⁴, Wei Chen⁵

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China.
² State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: edyulei@126.com.
³ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China.
⁴ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: fanliuping@jiangnan.edu.cn.
⁵ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China.

PMID: 32629250
DOI: 10.1016/j.scitotenv.2020.140429

Review

Gut microbiota: A target for heavy metal toxicity and a probiotic protective strategy

Hui Duan et al. Sci Total Environ. 2020.

. 2020 Nov 10:742:140429.

doi: 10.1016/j.scitotenv.2020.140429. Epub 2020 Jun 25.

Authors

Hui Duan¹, Leilei Yu², Fengwei Tian³, Qixiao Zhai³, Liuping Fan⁴, Wei Chen⁵

Affiliations

¹ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China.
² State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: edyulei@126.com.
³ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China.
⁴ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China. Electronic address: fanliuping@jiangnan.edu.cn.
⁵ State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu 214122, China; International Joint Research Laboratory for Probiotics at Jiangnan University, Wuxi, Jiangsu 214122, China.

PMID: 32629250
DOI: 10.1016/j.scitotenv.2020.140429

Abstract

There is growing epidemiological evidence that heavy metals (HMs) may contribute to the progression of various metabolic diseases and that the etiology and progression of these diseases is partly due to HM-induced perturbations of the gut microbiota. Importantly, the gut microbiota are the first line of defense against the toxic effects of HMs, and there is a bidirectional relationship between the two. Thus, HM exposure alters the composition and metabolic profile of the gut microbiota at the functional level, and in turn, the gut microbiota alter the uptake and metabolism of HMs by acting as a physical barrier to HM absorption and by altering the pH, oxidative balance, and concentrations of detoxification enzymes or proteins involved in HM metabolism. Moreover, the gut microbiota can affect the integrity of the intestinal barrier, which may also in turn affect the absorption of HMs. Specifically, probiotic have been shown to reduce the absorption of HMs in the intestinal tract via the enhancement of intestinal HM sequestration, detoxification of HMs in the gut, changing the expression of metal transporter proteins, and maintaining the gut barrier function. This review is a summary of the bidirectional relationship between HMs and gut microbiota and of the probiotic-based protective strategies against HM-induced gut dysbiosis, with reference to strategies used in the food industry or for medically alleviating HM toxicity.

Keywords: Gut dysbiosis; Gut microbiota; Heavy metal; Probiotic.

PubMed Disclaimer

Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Cited by

Toxic and essential metals: metabolic interactions with the gut microbiota and health implications.
Zhu Q, Chen B, Zhang F, Zhang B, Guo Y, Pang M, Huang L, Wang T. Zhu Q, et al. Front Nutr. 2024 Jul 29;11:1448388. doi: 10.3389/fnut.2024.1448388. eCollection 2024. Front Nutr. 2024. PMID: 39135557 Free PMC article. Review.
Harnessing the power of probiotic strains in functional foods: nutritive, therapeutic, and next-generation challenges.
Anwer M, Wei MQ. Anwer M, et al. Food Sci Biotechnol. 2024 Jun 20;33(9):2081-2095. doi: 10.1007/s10068-024-01630-z. eCollection 2024 Jul. Food Sci Biotechnol. 2024. PMID: 39130669 Free PMC article. Review.
Guardians of the Gut: Harnessing the Power of Probiotic Microbiota and Their Exopolysaccharides to Mitigate Heavy Metal Toxicity in Human for Better Health.
Dahiya P, Kumari S, Behl M, Kashyap A, Kumari D, Thakur K, Devi M, Kumari N, Kaushik N, Walia A, Bhatt AK, Bhatia RK. Dahiya P, et al. Probiotics Antimicrob Proteins. 2024 May 11. doi: 10.1007/s12602-024-10281-9. Online ahead of print. Probiotics Antimicrob Proteins. 2024. PMID: 38733461 Review.
Exploring the gut microbiota: lifestyle choices, disease associations, and personal genomics.
Pedroza Matute S, Iyavoo S. Pedroza Matute S, et al. Front Nutr. 2023 Oct 5;10:1225120. doi: 10.3389/fnut.2023.1225120. eCollection 2023. Front Nutr. 2023. PMID: 37867494 Free PMC article. Review.
Assessing the Effects of Dietary Cadmium Exposure on the Gastrointestinal Tract of Beef Cattle via Microbiota and Transcriptome Profile.
Xu X, Xu Z, Yang B, Yi K, He F, Sun A, Li J, Luo Y, Wang J. Xu X, et al. Animals (Basel). 2023 Oct 5;13(19):3104. doi: 10.3390/ani13193104. Animals (Basel). 2023. PMID: 37835710 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Gut microbiota: A target for heavy metal toxicity and a probiotic protective strategy

Affiliations

Gut microbiota: A target for heavy metal toxicity and a probiotic protective strategy

Authors

Affiliations

Abstract

Conflict of interest statement

Similar articles

Cited by

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources