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Review
. 2020 Aug-Sep;28(7-8):742-754.
doi: 10.1080/1061186X.2020.1793990. Epub 2020 Jul 16.

Pharmacological and non-pharmacological efforts at prevention, mitigation, and treatment for COVID-19

Mohammed M Alvi  1   2 , Sowmya Sivasankaran  1 , Mahima Singh  1
Affiliations
Review

Pharmacological and non-pharmacological efforts at prevention, mitigation, and treatment for COVID-19

Mohammed M Alvi et al. J Drug Target. 2020 Aug-Sep.

Abstract

A global outbreak of the SARS-CoV-2 virus has infected millions of people over a short period of time. The communicability and increased mortality from the SARS-CoV-2 infection mandated the WHO to declare COVID-19 a worldwide pandemic. The virus outbreak has spread when there are no approved vaccines, treatments, or prophylactic therapies available. Researchers from all over the world have prioritised development of vaccines and antivirals. Several vaccine projects have seen successes in preclinical, phase I, and phase II clinical trials using recombinant DNA, mRNA, live attenuated virus, S-protein subunits, virus like particles, and viral vectors. Initial findings from antivirals such as remdesivir, favipiravir, danoprevir or lopinavir with ritonavir are presented. Immunomodulatory molecules such as sarilumab, tocilizumab, janus kinase inhibitors, and hyperimmune convalescent plasma have mixed outcomes from initial clinical findings; however, pending randomised controlled trials will assist national health institutions to make treatment recommendations for COVID-19. Where compassionate use of remdesivir has shown some benefits, therapies such as hydroxychloroquine have proven harmful due to their toxicities. This review discusses pharmacological interventions at play and evidence-based successes and limitations of non-pharmacological therapies such as social distancing, personal protective equipment, and ventilator support associated with the prevention and treatment of COVID-19.

Keywords: COVID-19; SARS-CoV-2; antiviral; contact tracing; convalescent plasma; pandemic; personal protective equipment; social distancing; vaccine; ventilator support.

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