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Review
. 2021 Jan;93(1):323-335.
doi: 10.1002/jmv.26294. Epub 2020 Jul 22.

Extrapulmonary complications of COVID-19: A multisystem disease?

Kenneth I Zheng  1 , Gong Feng  2 , Wen-Yue Liu  3 , Giovanni Targher  4 , Christopher D Byrne  5 , Ming-Hua Zheng  1
Affiliations
Review

Extrapulmonary complications of COVID-19: A multisystem disease?

Kenneth I Zheng et al. J Med Virol. 2021 Jan.

Abstract

The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been recently declared a pandemic by the World Health Organization. In addition to its acute respiratory manifestations, SARS-CoV-2 may also adversely affect other organ systems. To date, however, there is a very limited understanding of the extent and management of COVID-19-related conditions outside of the pulmonary system. This narrative review provides an overview of the current literature about the extrapulmonary manifestations of COVID-19 that may affect the urinary, cardiovascular, gastrointestinal, hematological, hematopoietic, neurological, or reproductive systems. This review also describes the current understanding of the extrapulmonary complications caused by COVID-19 to improve the management and prognosis of patients with COVID-19.

Keywords: COVID-19; SARS-CoV-2; extrapulmonary manifestations; management.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Schematic figure showing the potential complications of COVID‐19 affecting organ systems. COVID‐19, coronavirus disease 2019
See this image and copyright information in PMC

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