Association of low-level inorganic arsenic exposure from rice with age-standardized mortality risk of cardiovascular disease (CVD) in England and Wales
- PMID: 32659549
- DOI: 10.1016/j.scitotenv.2020.140534
Association of low-level inorganic arsenic exposure from rice with age-standardized mortality risk of cardiovascular disease (CVD) in England and Wales
Abstract
Adverse health outcomes, including death from cardiovascular disease (CVD), arising from chronic exposure to inorganic arsenic (iAs) are well documented. Consumption of rice is a major iAs exposure route for over 3 billion people, however, there is still a lack of epidemiological evidence demonstrating the association between iAs exposure from rice intake and CVD risks. We explored this potential association through an ecological study using data at local authority level across England and Wales. Local authority level daily per capita iAs exposure from rice (E-iAsing,rice) was estimated using ethnicity as a proxy for class of rice consumption. A series of linear and non-linear models were applied to estimate the association between E-iAsing,rice and CVD age-standardized mortality rate (ASMR), using Akaike's Information Criterion as the principle model selection criterion. When adjusted for significant confounders, notably smoking prevalence, education level, employment rate, overweight percentage, PM2.5, female percentage and medical and care establishments, the preferred non-linear model indicated that CVD risks increased with iAs exposure from rice at exposures above 0.3 μg/person/day. Also, the best-fitted linear model indicated that CVD ASMR in the highest quartile of iAs exposure (0.375-2.71 μg/person/day) was 1.06 (1.02, 1.11; p-trend <0.001) times higher than that in the lowest quartile (<0.265 μg/person/day). Notwithstanding the well-known limitations of ecological studies, this study further suggests exposure to iAs, including from rice intake, as a potentially important confounder for studies of the factors controlling CVD risks.
Keywords: Cardiovascular disease; Ecological study; Inorganic arsenic; Non-linear association; Rice consumption.
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Conflict of interest statement
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Similar articles
-
Exploratory study of the association in the United Kingdom between hypertension and inorganic arsenic (iAs) intake from rice and rice products.Environ Geochem Health. 2021 Jul;43(7):2505-2538. doi: 10.1007/s10653-020-00573-8. Epub 2020 Apr 28. Environ Geochem Health. 2021. PMID: 32347515 Free PMC article.
-
Estimating inorganic arsenic exposure from rice intake in Chinese Urban Population.Environ Pollut. 2020 Aug;263(Pt A):114397. doi: 10.1016/j.envpol.2020.114397. Epub 2020 Mar 17. Environ Pollut. 2020. PMID: 32220775
-
Estimating Inorganic Arsenic Exposure from U.S. Rice and Total Water Intakes.Environ Health Perspect. 2017 May 30;125(5):057005. doi: 10.1289/EHP418. Environ Health Perspect. 2017. PMID: 28572075 Free PMC article.
-
A Comprehensive Review of Arsenic Exposure and Risk from Rice and a Risk Assessment among a Cohort of Adolescents in Kunming, China.Int J Environ Res Public Health. 2018 Oct 8;15(10):2191. doi: 10.3390/ijerph15102191. Int J Environ Res Public Health. 2018. PMID: 30297612 Free PMC article. Review.
-
Association of low-level arsenic exposure in drinking water with cardiovascular disease: a systematic review and risk assessment.Toxicology. 2014 Sep 2;323:78-94. doi: 10.1016/j.tox.2014.06.008. Epub 2014 Jun 20. Toxicology. 2014. PMID: 24953689 Review.
Cited by
-
Multifaceted response mechanisms of Oryza sativa L. 'KDML105' to high arsenite and arsenate stress levels.Environ Sci Pollut Res Int. 2024 Feb;31(9):13816-13832. doi: 10.1007/s11356-024-32122-6. Epub 2024 Jan 24. Environ Sci Pollut Res Int. 2024. PMID: 38265595
-
Update of the risk assessment of inorganic arsenic in food.EFSA J. 2024 Jan 18;22(1):e8488. doi: 10.2903/j.efsa.2024.8488. eCollection 2024 Jan. EFSA J. 2024. PMID: 38239496 Free PMC article.
-
Arsenic and heavy metal contents in white rice samples from rainfed paddy fields in Yangon division, Myanmar-Natural background levels?PLoS One. 2023 Mar 24;18(3):e0283420. doi: 10.1371/journal.pone.0283420. eCollection 2023. PLoS One. 2023. PMID: 36961793 Free PMC article.
-
Overview of the cardiovascular effects of environmental metals: New preclinical and clinical insights.Toxicol Appl Pharmacol. 2022 Nov 1;454:116247. doi: 10.1016/j.taap.2022.116247. Epub 2022 Sep 17. Toxicol Appl Pharmacol. 2022. PMID: 36122736 Free PMC article.
-
Soil and water pollution and human health: what should cardiologists worry about?Cardiovasc Res. 2023 Mar 31;119(2):440-449. doi: 10.1093/cvr/cvac082. Cardiovasc Res. 2023. PMID: 35772469 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical