Natural products and their derivatives: Promising modulators of tumor immunotherapy
- PMID: 32678943
- PMCID: PMC7496826
- DOI: 10.1002/JLB.3MR0320-444R
Natural products and their derivatives: Promising modulators of tumor immunotherapy
Abstract
A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option in cancer. In recent decades, accumulated studies have revealed the anticancer activities of natural products and their derivatives. Increasing interest has been driven toward finding novel potential modulators of tumor immunotherapy from natural products, a hot research topic worldwide. These works of research mainly focused on natural products, including polyphenols (e.g., curcumin, resveratrol), cardiotonic steroids (e.g., bufalin and digoxin), terpenoids (e.g., paclitaxel and artemisinins), and polysaccharide extracts (e.g., lentinan). Compelling data highlight that natural products have a promising future in tumor immunotherapy. Considering the importance and significance of this topic, we initially discussed the integrated research progress of natural products and their derivatives, including target T cells, macrophages, B cells, NKs, regulatory T cells, myeloid-derived suppressor cells, inflammatory cytokines and chemokines, immunogenic cell death, and immune checkpoints. Furthermore, these natural compounds inactivate several key pathways, including NF-κB, PI3K/Akt, MAPK, and JAK/STAT pathways. Here, we performed a deep generalization, analysis, and summarization of the previous achievements, recent progress, and the bottlenecks in the development of natural products as tumor immunotherapy. We expect this review to provide some insight for guiding future research.
Keywords: Tregs; cardiotonic steroids; polyphenolics; polysaccharides; terpenoids; tumor immunotherapy.
© 2020 The Authors. Journal of Leukocyte Biology published by Wiley Periodicals LLC on behalf of Society for Leukocyte Biology.
Conflict of interest statement
The authors declare no conflicts of interest.
Figures
![FIGURE 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7496826/bin/JLB-108-493-g001.gif)
![FIGURE 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/7496826/bin/JLB-108-493-g002.gif)
Similar articles
-
Targeting CD8+ T cells with natural products for tumor therapy: Revealing insights into the mechanisms.Phytomedicine. 2024 Jul;129:155608. doi: 10.1016/j.phymed.2024.155608. Epub 2024 Apr 8. Phytomedicine. 2024. PMID: 38642413 Review.
-
Research advance of natural products in tumor immunotherapy.Front Immunol. 2022 Sep 2;13:972345. doi: 10.3389/fimmu.2022.972345. eCollection 2022. Front Immunol. 2022. PMID: 36159787 Free PMC article. Review.
-
Advances in plant-derived natural products for antitumor immunotherapy.Arch Pharm Res. 2021 Nov;44(11):987-1011. doi: 10.1007/s12272-021-01355-1. Epub 2021 Nov 9. Arch Pharm Res. 2021. PMID: 34751930 Review.
-
Natural Immunomodulators 2018.J Immunol Res. 2019 Nov 3;2019:4341698. doi: 10.1155/2019/4341698. eCollection 2019. J Immunol Res. 2019. PMID: 31781677 Free PMC article. No abstract available.
-
Natural Polysaccharides with Immunomodulatory Activities.Mini Rev Med Chem. 2020;20(2):96-106. doi: 10.2174/1389557519666190913151632. Mini Rev Med Chem. 2020. PMID: 31518223 Review.
Cited by
-
Inflammation and cancer: friend or foe?Front Pharmacol. 2024 May 10;15:1385479. doi: 10.3389/fphar.2024.1385479. eCollection 2024. Front Pharmacol. 2024. PMID: 38799159 Free PMC article. Review.
-
Artemisinic acid attenuates osteoclast formation and titanium particle-induced osteolysis via inhibition of RANKL-induced ROS accumulation and MAPK and NF-κB signaling pathways.Front Pharmacol. 2024 May 1;15:1345380. doi: 10.3389/fphar.2024.1345380. eCollection 2024. Front Pharmacol. 2024. PMID: 38751789 Free PMC article.
-
Advances in Antitumor Effects Using Liposomal Citrinin in Induced Breast Cancer Model.Pharmaceutics. 2024 Jan 26;16(2):174. doi: 10.3390/pharmaceutics16020174. Pharmaceutics. 2024. PMID: 38399235 Free PMC article.
-
A review of natural products targeting tumor immune microenvironments for the treatment of lung cancer.Front Immunol. 2024 Feb 1;15:1343316. doi: 10.3389/fimmu.2024.1343316. eCollection 2024. Front Immunol. 2024. PMID: 38361933 Free PMC article. Review.
-
A study on the role of Taxifolin in inducing apoptosis of pancreatic cancer cells: screening results using weighted gene co-expression network analysis.Aging (Albany NY). 2024 Feb 1;16(3):2617-2637. doi: 10.18632/aging.205500. Epub 2024 Feb 1. Aging (Albany NY). 2024. PMID: 38305809 Free PMC article.
References
-
- Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: gLOBOCAN sources and methods. Int J Cancer. 2019;144:1941‐1953. - PubMed
-
- Galon J, Bruni D. Tumor immunology and tumor evolution: intertwined histories. Immunity. 2020;52:55‐81. - PubMed
-
- Garner H, de Visser KE. Immune crosstalk in cancer progression and metastatic spread: a complex conversation. Nat Rev Immunol. 2020. - PubMed
-
- Ouyang W, O'Garra A. IL‐10 family cytokines IL‐10 and IL‐22: from basic science to clinical translation. Immunity. 2019;50:871‐891. - PubMed