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. 2020 Nov;34(11):e23499.
doi: 10.1002/jcla.23499. Epub 2020 Aug 13.

Clinical characteristics of H-type hypertension and its relationship with the MTHFR C677T polymorphism in a Zhuang population from Guangxi, China

Liu Qiang Huang  1 , Chong Xin Wu  1 , Hua Qing Wei  1 , Ge Xu  2
Affiliations

Clinical characteristics of H-type hypertension and its relationship with the MTHFR C677T polymorphism in a Zhuang population from Guangxi, China

Liu Qiang Huang et al. J Clin Lab Anal. 2020 Nov.

Abstract

Objective: This study was designed to assess the clinical presentation of patients with H-type hypertension who were of Zhuang nationality in Guangxi, China. The relationship between the C677T polymorphism in the MTHFR gene and H-type hypertension was also assessed.

Methods: This was a case-control study in which 185 Zhuang nationality patients with hypertension that had been hospitalized at the Wuming Hospital of Guangxi Medical University between February 2018 and December 2018 were assessed for plasma homocysteine (Hcy) levels. These levels were used to divide patients into H-type (>15 μmol/L) and non-H-type (≤15 μmol/L) hypertension groups. Patient clinical data were then analyzed, and PCR was used to analyze samples from all patients for the presence of the C677T polymorphism in the MTHFR gene. Differences between these two groups of hypertension patients were then compared using appropriate statistical methods.

Results: We found that relative to patients in the non-H-type hypertension group, patients in the H-type hypertension group exhibited significant differences in sex, age, urea nitrogen levels, creatinine levels, and uric acid levels. There were, however, no significant differences between these two groups with respect to interventricular septum thickness, left ventricular posterior wall thickness, or ejection fraction. We did not detect any association between the MTHFR gene C677T polymorphism and H-type hypertension in Zhuang nationality individuals in Guangxi.

Conclusion: Risk of H-type hypertension is not associated with the MTHFR C677T polymorphism in hypertensive individuals of Guangxi Zhuang nationality in China.

Keywords: MTHFR; Zhuang nationality population; hyperhomocysteinemia; hypertension; polymorphism.

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