Tannic acid, a promising anti-photoaging agent: Evidences of its antioxidant and anti-wrinkle potentials, and its ability to prevent photodamage and MMP-1 expression in L929 fibroblasts exposed to UVB
- PMID: 32858160
- DOI: 10.1016/j.freeradbiomed.2020.08.019
Tannic acid, a promising anti-photoaging agent: Evidences of its antioxidant and anti-wrinkle potentials, and its ability to prevent photodamage and MMP-1 expression in L929 fibroblasts exposed to UVB
Abstract
Chronic and unprotect UV exposure leads to skin oxidative stress, following accumulation of damaged cellular components and downstream activation of specific signaling pathways, culminating in premature skin aging (photoaging). In this concern, polyphenols have been proposed for the prevention of skin disorders UV-generated. In the present study, we compared gallic acid (GA) and tannic acid (TA) regarding their potentials in prevent photoaging, using cell-free assays. The most promising compound was further investigated for its photoprotection abilities in UVB-irradiated L929 fibroblasts. TA was more efficient in scavenging radicals DPPH•, superoxide anion, peroxyl, nitric oxide and peroxynitrite, and to reduce ferric ions. Although GA and TA exhibited similar inhibitory activity towards collagenase, TA was more potent in inhibit elastase. In addition, TA presented a broader UV absorption spectrum. Furthermore, TA treatment in UVB-irradiated cells attenuated redox imbalance, as observed by its ability to inhibit ROS production, NADPH oxidase activation and depletion of endogenous antioxidant defense system. Moreover, TA treatment prevented cellular photodamage and subsequently photoaging, by inhibiting lipid peroxidation, depolarization of mitochondrial transmembrane potential, DNA damage, and MMP-1 expression, a protein closely related to the structural degeneration of the dermis extracellular matrix. In conclusion, the results indicate the potential of TA in act as anti-photoaging agent, due to its potent antioxidant, anti-collagenase and anti-elastase activities, and UV-absorption effects, and its ability in prevent oxidative stress, oxidative damages and MMP-1 induction in UVB-irradiated L929 fibroblasts.
Keywords: Gallic acid; Oxidative stress; Photoaging; Tannic acid; UVB.
Copyright © 2020 Elsevier Inc. All rights reserved.
Similar articles
-
Cerium Oxide Nanoparticles Conjugated with Tannic Acid Prevent UVB-Induced Oxidative Stress in Fibroblasts: Evidence of a Promising Anti-Photodamage Agent.Antioxidants (Basel). 2023 Jan 12;12(1):190. doi: 10.3390/antiox12010190. Antioxidants (Basel). 2023. PMID: 36671052 Free PMC article.
-
Abilities of protocatechuic acid and its alkyl esters, ethyl and heptyl protocatechuates, to counteract UVB-induced oxidative injuries and photoaging in fibroblasts L929 cell line.J Photochem Photobiol B. 2020 Jan;203:111771. doi: 10.1016/j.jphotobiol.2019.111771. Epub 2019 Dec 30. J Photochem Photobiol B. 2020. PMID: 31911399
-
Gallic acid regulates skin photoaging in UVB-exposed fibroblast and hairless mice.Phytother Res. 2014 Dec;28(12):1778-88. doi: 10.1002/ptr.5198. Epub 2014 Aug 8. Phytother Res. 2014. PMID: 25131997
-
Anti-photoaging and photoprotective compounds derived from marine organisms.Mar Drugs. 2010 Apr 8;8(4):1189-202. doi: 10.3390/md8041189. Mar Drugs. 2010. PMID: 20479974 Free PMC article. Review.
-
Solar UV irradiation and dermal photoaging.J Photochem Photobiol B. 2001 Oct;63(1-3):41-51. doi: 10.1016/s1011-1344(01)00201-9. J Photochem Photobiol B. 2001. PMID: 11684450 Review.
Cited by
-
Cell-homing and immunomodulatory composite hydrogels for effective wound healing with neovascularization.Bioact Mater. 2024 Mar 5;36:185-202. doi: 10.1016/j.bioactmat.2024.02.029. eCollection 2024 Jun. Bioact Mater. 2024. PMID: 38463552 Free PMC article.
-
Phytochemical Profiling and Biological Activities of Quercus sp. Galls (Oak Galls): A Systematic Review of Studies Published in the Last 5 Years.Plants (Basel). 2023 Nov 16;12(22):3873. doi: 10.3390/plants12223873. Plants (Basel). 2023. PMID: 38005770 Free PMC article. Review.
-
Molecular interactions of tannic acid and matrix metalloproteinases 2 and 9.Comput Struct Biotechnol J. 2023 Apr 14;21:2792-2800. doi: 10.1016/j.csbj.2023.04.011. eCollection 2023. Comput Struct Biotechnol J. 2023. PMID: 37181658 Free PMC article.
-
β-Carboline-α-aminophosphonate Derivative: A Promising Antitumor Agent for Breast Cancer Treatment.Molecules. 2023 May 8;28(9):3949. doi: 10.3390/molecules28093949. Molecules. 2023. PMID: 37175359 Free PMC article.
-
Exploring Mycosporine-like Amino Acid UV-Absorbing Natural Products for a New Generation of Environmentally Friendly Sunscreens.Mar Drugs. 2023 Apr 19;21(4):253. doi: 10.3390/md21040253. Mar Drugs. 2023. PMID: 37103392 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical