The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver

doi:10.1016/j.freeradbiomed.2020.11.022

. 2021 Jan:162:141-148.

doi: 10.1016/j.freeradbiomed.2020.11.022. Epub 2020 Nov 26.

The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver

Ying Zhang¹, Jiyoung Park², Seong-Jeong Han³, Iha Park⁴, Thang Nguyen Huu⁴, Jong-Suk Kim⁵, Hyun Ae Woo⁶, Seung-Rock Lee⁷

Affiliations

¹ Department of Cell Biology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
² College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, South Korea.
³ COTDE Inc. 19-3, Ugakgol-gil, Susin-myeon, Cheonan-si, Chungcheongnam-do, 330-882, South Korea.
⁴ Department of Biochemistry, Department of Biomedical Sciences, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, 501-190, South Korea.
⁵ Department of Biochemistry, Institute of Medical Science, Chonbuk National University Medical School, Jeonju, 560-182, South Korea.
⁶ College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, South Korea. Electronic address: hawoo@ewha.ac.kr.
⁷ Department of Biochemistry, Department of Biomedical Sciences, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, 501-190, South Korea. Electronic address: leesr@jnu.ac.kr.

PMID: 33249138
DOI: 10.1016/j.freeradbiomed.2020.11.022

The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver

Ying Zhang et al. Free Radic Biol Med. 2021 Jan.

. 2021 Jan:162:141-148.

doi: 10.1016/j.freeradbiomed.2020.11.022. Epub 2020 Nov 26.

Authors

Ying Zhang¹, Jiyoung Park², Seong-Jeong Han³, Iha Park⁴, Thang Nguyen Huu⁴, Jong-Suk Kim⁵, Hyun Ae Woo⁶, Seung-Rock Lee⁷

Affiliations

¹ Department of Cell Biology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China.
² College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, South Korea.
³ COTDE Inc. 19-3, Ugakgol-gil, Susin-myeon, Cheonan-si, Chungcheongnam-do, 330-882, South Korea.
⁴ Department of Biochemistry, Department of Biomedical Sciences, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, 501-190, South Korea.
⁵ Department of Biochemistry, Institute of Medical Science, Chonbuk National University Medical School, Jeonju, 560-182, South Korea.
⁶ College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, 120-750, South Korea. Electronic address: hawoo@ewha.ac.kr.
⁷ Department of Biochemistry, Department of Biomedical Sciences, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, 501-190, South Korea. Electronic address: leesr@jnu.ac.kr.

PMID: 33249138
DOI: 10.1016/j.freeradbiomed.2020.11.022

Abstract

Hepatic steatosis and subsequent fatty liver disease are developed in response to alcohol consumption. Reactive oxygen species (ROS) are thought to play an important role in the alcoholic fatty liver disease (AFLD). However, the molecular targets of ROS and the underlying cellular mechanisms are unknown. Here, we investigate roles of peroxiredoxin III and redox regulation of phosphatase and tension homolog deleted on chromosome 10 (PTEN) in the alcoholic fatty liver. Alcohol-induced mitochondrial oxidative stress was found to contribute to reversible oxidation of PTEN, which results in Akt and MAPK hyperactivation with elevated levels of the lipogenesis regulators SREBP1c and PPARγ. Moreover, mitochondrial peroxiredoxin III was found to have antagonistic effects on lipogenesis via the redox regulation of PTEN by removing ROS, upon alcohol exposure. This study demonstrated that redox regulation of PTEN and peroxiredoxin III play crucial roles in the development of AFLD.

Keywords: Alcohol; Alcoholic fatty liver disease; Hepatic steatosis; PTEN; Peroxiredoxin III; Reactive oxygen species.

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The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver

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The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver

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