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Review
. 2020 Dec 7;6(12):e05662.
doi: 10.1016/j.heliyon.2020.e05662. eCollection 2020 Dec.

Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research

Jhansi Nathan  1   2 , Rajaretinam Rajesh Kannan  2
Affiliations
Review

Antiangiogenic molecules from marine actinomycetes and the importance of using zebrafish model in cancer research

Jhansi Nathan et al. Heliyon. .

Abstract

Blood vessel sprouting from pre-existing vessels or angiogenesis plays a significant role in tumour progression. Development of novel biomolecules from marine natural sources has a promising role in drug discovery specifically in the area of antiangiogenic chemotherapeutics. Symbiotic actinomycetes from marine origin proved to be potent and valuable sources of antiangiogenic compounds. Zebrafish represent a well-established model for small molecular screening and employed to study tumour angiogenesis over the last decade. Use of zebrafish has increased in the laboratory due to its various advantages like rapid embryo development, optically transparent embryos, large clutch size of embryos and most importantly high genetic conservation comparable to humans. Zebrafish also shares similar physiopathology of tumour angiogenesis with humans and with these advantages, zebrafish has become a popular model in the past decade to study on angiogenesis related disorders like diabetic retinopathy and cancer. This review focuses on the importance of antiangiogenic compounds from marine actinomycetes and utility of zebrafish in cancer angiogenesis research.

Keywords: Actinomycetes; Angiogenesis; Bioactive molecules; Biomedical engineering; Biotechnology; Cancer research; Danio rerio; Developmental biology; Genetics; Molecular biology; Pharmaceutical science; Proteins; Toxicology; Transgenic model; Xenograft model.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The process of angiogenesis.
Figure 2
Figure 2
Importance of zebrafish model to study antiangiogenic compounds from marine actinomycetes (a. Distribution of actinomycetes from marine sources [14], b. Antiangiogenic biomolecules from marine actinomycetes, c. Advantages of zebrafish model in cancer research).
Figure 3
Figure 3
Marine derived drugs targeting tumour angiogenesis.
Figure 4
Figure 4
Structures of marine actinomycetes derived compounds that possess antiangiogenic potential.
Figure 5
Figure 5
Confocal fluorescence imaging shows blood vessels in green and lymphatics in red. (Adapted from Okuda et al., 2012 [107]). [Abbreviations: DLV- dorsal longitudinal vein, DLAV- dorsal longitudinal anastomotic vessel, DA- dorsal aorta, Se- intersegmental vessel, CA- caudal artery, CV- caudal vein, SIV-subintestinal vein, SIA- supraintestinal artery, PCV-posterior cardinal vein.].
See this image and copyright information in PMC

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