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. 1988 Jun;85(12):4526-9.
doi: 10.1073/pnas.85.12.4526.

Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses

R Vlasak  1 , W Luytjes, W Spaan, P Palese
Affiliations

Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses

R Vlasak et al. Proc Natl Acad Sci U S A. 1988 Jun.

Abstract

Human coronavirus OC43 and bovine coronavirus elute from agglutinated chicken erythrocytes when incubated at 37 degrees C, suggesting the presence of a receptor-destroying enzyme. Moreover, bovine coronavirus exhibits an acetylesterase activity in vitro using bovine submaxillary mucin as substrate similar to the enzymatic activity found in influenza C viruses. Furthermore, pretreatment of erythrocytes with either influenza C virus or bovine coronavirus eliminates subsequent binding and agglutination by either coronaviruses or influenza C virus, whereas binding of influenza A virus remains intact. In addition, hemagglutination by coronaviruses can be inhibited by pretreatment of erythrocytes with Arthrobacter ureafaciens or Clostridium perfringens neuraminidase or by addition of sialic acid-containing gangliosides. These results suggest that, like influenza C viruses, human coronavirus OC43 and bovine coronavirus recognize O-acetylated sialic acid or a similar derivative as cell receptor.

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References

    1. Am J Epidemiol. 1970 Jun;91(6):585-92 - PubMed
    1. J Exp Med. 1950 Feb;91(2):177-84 - PubMed
    1. Virology. 1972 May;48(2):516-27 - PubMed
    1. Vestn Akad Med Nauk SSSR. 1972;27(6):40-3 - PubMed
    1. J Infect Dis. 1974 Mar;129(3):271-6 - PubMed

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